ArticleMolecules (Basel, Switzerland)2026
In Vitro Antiproliferative Effects of Benzothiazole-Based Aminosquaraine Dyes Against Cancer Cell Lines.
Elisabete Alves, João L Serrano, Ahmed Al-Najada, Sara Cegonho, Vânia Graça, Eurico Lima, Alexandra Varges, Adriana O Santos, Paulo Almeida, Paulo F Santos and 1 more
Abstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
11 authors.
Elisabete AlvesRISE-Health, Faculty of Health Sciences, University of Beira Interior, Avenida Infante D. Henrique, 6201-506 Covilhã, Portugal.
João L SerranoRISE-Health, Department of Chemistry, Faculty of Sciences, University of Beira Interior, Rua Marquês de Ávila e Bolama, 6201-001 Covilhã, Portugal.ORCID 0000-0002-0513-7976 Ahmed Al-NajadaKing Abdulaziz City for Science and Technology, P.O. Box 6086, Riyadh 11442, Saudi Arabia.
Sara CegonhoRISE-Health, Faculty of Health Sciences, University of Beira Interior, Avenida Infante D. Henrique, 6201-506 Covilhã, Portugal.
Vânia GraçaCQ-VR-Chemistry Centre of Vila Real, University of Trás-os-Montes and Alto Douro, Quinta de Prados, 5001-801 Vila Real, Portugal.ORCID 0000-0003-2124-1017 Eurico LimaCQ-VR-Chemistry Centre of Vila Real, University of Trás-os-Montes and Alto Douro, Quinta de Prados, 5001-801 Vila Real, Portugal.ORCID 0000-0002-9402-8949 Alexandra VargesRISE-Health, Department of Chemistry, Faculty of Sciences, University of Beira Interior, Rua Marquês de Ávila e Bolama, 6201-001 Covilhã, Portugal.
Adriana O SantosRISE-Health, Faculty of Health Sciences, University of Beira Interior, Avenida Infante D. Henrique, 6201-506 Covilhã, Portugal.ORCID 0000-0002-1224-9191 Paulo AlmeidaRISE-Health, Department of Chemistry, Faculty of Sciences, University of Beira Interior, Rua Marquês de Ávila e Bolama, 6201-001 Covilhã, Portugal.ORCID 0000-0003-0110-4795 Paulo F SantosCQ-VR-Chemistry Centre of Vila Real, University of Trás-os-Montes and Alto Douro, Quinta de Prados, 5001-801 Vila Real, Portugal.ORCID 0000-0002-8723-4373 Samuel M SilvestreRISE-Health, Department of Chemistry, Faculty of Sciences, University of Beira Interior, Rua Marquês de Ávila e Bolama, 6201-001 Covilhã, Portugal.ORCID 0000-0003-4297-5108 Funding
National NMR Network (PTNMR) - FEDER Infrastructure Project 022161Portuguese Foundation for Science and Technology (FCT) and European Regional Development Fund (FEDER) UIDB/00616/2020Portuguese Foundation for Science and Technology (FCT) and European Regional Development Fund (FEDER) UIDB/0079/2020Portuguese Foundation for Science and Technology (FCT) and European Regional Development Fund (FEDER) UIDP/00709/2020PPBI-Portuguese Platform of BioImaging Project PO-CI-01-0145-FEDER-022122
6 · The paper itselfAbstract
The introduction of amine groups into the four-membered central ring of squaraine dyes is expected to enhance the intrinsic cytotoxicity of this scaffold. In this study, the biological effects of eight benzothiazole-based aminosquaraine dyes were investigated by varying the length of the
Indexed as
Antineoplastic AgentsBenzothiazolesColoring AgentsCyclobutanesPhenolsApoptosisCell CycleCell Cycle CheckpointsCell Line, TumorCell ProliferationHumansAntineoplastic AgentsbenzothiazoleBenzothiazolesColoring AgentsCyclobutanesPhenolssquaraineaminosquaraine dyesapoptosiscell cyclecytotoxicityselectivity
Identifiers
PMID42123900
PMCPMC13165350
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