ArticleMolecules (Basel, Switzerland)2026
Synthesis, Structure, and Antitumor Activity of Heterocyclic 2-[4-(Dimethylamino)benzyl]-3-oxoisoindoline-4-carboxylates.
Gulim K Mukusheva, Roza I Jalmakhanbetova, Zharkyn Zh Zhumagaliyeva, Gulzhaukhar A Toktarbay, Irina A Kolesnik, Ekaterina A Akishina, Evgenij A Dikusar, Vladimir I Potkin, Aliaksandr L Pushkarchuk, Tatiana I Terpinskaya and 3 more
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In one paragraphArticle in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
13 authors.
Gulim K MukushevaChemistry Faculty, NLC "Karaganda National Research University Named After Academician Ye.A. Buketov", Karaganda 100024, Kazakhstan.
Roza I JalmakhanbetovaDepartment of Chemistry, Institute of Natural Sciences, L.N. Gumilyov Eurasian National University, Astana 010000, Kazakhstan.ORCID 0000-0001-9937-275X Zharkyn Zh ZhumagaliyevaAstana International University, Astana 010000, Kazakhstan.
Gulzhaukhar A ToktarbayChemistry Faculty, NLC "Karaganda National Research University Named After Academician Ye.A. Buketov", Karaganda 100024, Kazakhstan.ORCID 0009-0003-8389-8046 Irina A KolesnikLaboratory of Chemistry of Heterocyclic Compounds, Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 220072 Minsk, Belarus.
Ekaterina A AkishinaLaboratory of Chemistry of Heterocyclic Compounds, Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 220072 Minsk, Belarus.ORCID 0000-0002-0803-8623 Evgenij A DikusarLaboratory of Chemistry of Heterocyclic Compounds, Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 220072 Minsk, Belarus.
Vladimir I PotkinLaboratory of Chemistry of Heterocyclic Compounds, Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 220072 Minsk, Belarus.ORCID 0000-0003-0250-837X Aliaksandr L PushkarchukLaboratory of Ion Exchange and Sorption, Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 220072 Minsk, Belarus.ORCID 0000-0001-8573-8212 Tatiana I TerpinskayaCenter of Medical Microbiology and Antibiotic Resistance, Institute of Physiology, National Academy of Sciences of Belarus, 220072 Minsk, Belarus.ORCID 0000-0002-4536-3580 Fedor I ZubkovFaculty of Science, Peoples Friendship University of Russia (RUDN University), Moscow 117198, Russia.ORCID 0000-0002-0289-0831 Mikhail S GrigorievFrumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Moscow 119071, Russia.ORCID 0000-0002-6363-5535 Hongwei ZhouCollege of Chemistry, Biology and Chemical Engineering, Jiaxing University, Jiaxing 314001, China.
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6 · The paper itselfAbstract
In this study, the synthesis of a series of alkaloid analogs-isoxazole and isothiazole esters of 2-substituted 3-oxoindoline-4-carboxylic acid was performed. The target derivatives were obtained by the carbodiimide method. It was established that the studied esters have low cytotoxicity and are able to enhance the effect of the anticancer drug carboplatin, taken in low doses (0.5-5 μM), by up to 30%. Quantum chemical modeling of the obtained compounds and their conjugates with carboplatin was carried out to analyze the relationship between various calculated parameters and the observed biological effects.
Indexed as
Antineoplastic AgentsCell Line, TumorHumansMolecular StructureStructure-Activity RelationshipAntineoplastic Agentsdrug synergismestersisoindolineisothiazoleisoxazolequantum chemical modelingquaternization
Identifiers
PMID42123892
PMCPMC13165306
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