Evidence map›Paper›PMID 42123875›Full record

ArticleMolecules (Basel, Switzerland)2026

5-(Benzofuran-2-yl)-3-(2-chloro-4-fluorobenzyl)-1,3,4-oxadiazol-2(3H)-one (GM-90663) Alleviates Dravet Syndrome via Inhibiting Monoamine Oxidase Activity.

Kyu-Seok Hwang, Se Hwan Ahn, Yuji Son, Seong Soon Kim, Dae-Seop Shin, Jung Yoon Yang, Chong Hak Chae, Michiko Nakamura, Il-Sung Jang, Gahyeon Kim and 7 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Kyu-Seok HwangTherapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.ORCID 0000-0003-4606-1354
Se Hwan AhnDepartment of Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
Yuji SonTherapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.ORCID 0009-0009-2207-2770
Seong Soon KimTherapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.ORCID 0000-0002-4762-8693
Dae-Seop ShinTherapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.ORCID 0000-0002-6641-5028
Jung Yoon YangTherapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.
Chong Hak ChaeTherapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.
Michiko NakamuraDepartment of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Republic of Korea.
Il-Sung JangDepartment of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Republic of Korea.
Gahyeon KimTherapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.
Dong Gun KimDepartment of Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
Pyeongkeun KimDepartment of Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.ORCID 0009-0004-1203-2533
Yerim HeoDepartment of Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
Sunjae BaeDepartment of Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
Hohjai LeeDepartment of Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.ORCID 0000-0002-6810-0206
Jin Hee AhnDepartment of Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.ORCID 0000-0002-6957-6062
Myung Ae BaeTherapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dravet syndrome (DS) is a severe, catastrophic childhood epilepsy predominantly caused by loss-of-function mutations in the

Indexed as

Epilepsies, MyoclonicMonoamine OxidaseMonoamine Oxidase InhibitorsOxadiazolesAnimalsDisease Models, AnimalHippocampusHumansMolecular Docking SimulationNAV1.1 Voltage-Gated Sodium ChannelZebrafishMonoamine OxidaseMonoamine Oxidase InhibitorsNAV1.1 Voltage-Gated Sodium ChannelOxadiazolesDravet syndromemonoamine oxidaseSCN1Atreatmentzebrafish

Identifiers

PMID42123875
PMCPMC13164629

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.