Evidence map›Paper›PMID 42123770›Full record

ReviewMolecules (Basel, Switzerland)2026

Bioactive Compounds in Coffee: Metabolism, Bioavailability and Health Effects-A Review.

Hajnal Finta, Sándor Pál, Margit Solymár, Zsuzsanna Faust, Marius-Călin Cherecheș, Florina Ruța, Daniela-Edith Ceană, Corneliu-Florin Buicu, Enikő Nemes-Nagy

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hajnal FintaDepartment of Public Health and Health Management, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania.ORCID 0009-0004-3167-5497
Sándor PálDepartment of Laboratory Medicine, University of Pécs, H-7633 Pécs, Hungary.ORCID 0000-0002-3993-7947
Margit SolymárDepartment of Laboratory Medicine, University of Pécs, H-7633 Pécs, Hungary.
Zsuzsanna FaustDepartment of Laboratory Medicine, University of Pécs, H-7633 Pécs, Hungary.
Marius-Călin CherecheșDepartment of Drug Industry and Pharmaceutical Management, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania.ORCID 0000-0001-8815-4693
Florina RuțaDepartment of Community Nutrition and Food Safety, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania.ORCID 0000-0001-5715-5220
Daniela-Edith CeanăDepartment of Public Health and Health Management, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania.ORCID 0009-0002-4732-1752
Corneliu-Florin BuicuDepartment of Public Health and Health Management, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania.ORCID 0000-0002-7378-5756
Enikő Nemes-NagyDepartment of Chemistry and Medical Biochemistry, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coffee is a very popular psychoactive beverage with a complex composition. Besides its stimulant effect due to caffeine, it contains several bioactive compounds with antioxidant properties and potent metabolic activity. Its clinical efficacy is fundamentally determined by the bioavailability and metabolic fate of its constituents. The bioactive components of coffee, such as polyphenols, melanoidins, phytosterols, biogenic amines, and carotenoids, have notable antioxidant, anti-inflammatory, and immunomodulatory effects. This review aims to present the main bioactive components of coffee, their biological effects, mechanisms of action, and the influence of preparation methods and individual variability on metabolic outcomes in common chronic diseases. The data are synthesized from clinical, prospective, and interventional studies to examine how processing variables and biological metabolism influence the health-promoting potential of coffee antioxidants. Brewing methods like hot filtration optimize the extraction of these antioxidants. Individual clinical outcomes are further modulated by genetic polymorphisms and gut microbiota variability, which influence the activation of the cellular Nrf2 antioxidant defense pathway.

Indexed as

AntioxidantsCoffeePhytochemicalsAnimalsAnti-Inflammatory AgentsBiological AvailabilityHumansPolymersPolyphenolsAnti-Inflammatory AgentsAntioxidantsCoffeemelanoidin polymersPhytochemicalsPolymersPolyphenolsbioactive compoundsbioavailabilitycardio-metabolic protectionchlorogenic acidscoffee antioxidantscoffee roastinggut microbiotamelanoidinsmetabolismNrf2 pathway

Identifiers

PMID42123770
PMCPMC13165461

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.