Evidence map›Paper›PMID 42123662›Full record

ArticleInternational journal of molecular sciences2026

Vasorelaxing Effect of Hydrolyzed Collagen from Salmon Skin in the Thoracic Aorta and Underlying Mechanisms.

Pimchanok Mungmuang, Amnart Onsa-Ard, Jiraporn Tocharus, Rattapong Sungnoon, Rungusa Pantan, Krisana Nilsuwan, Soottawat Benjakul, Chainarong Tocharus

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pimchanok MungmuangDepartment of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.ORCID 0009-0003-8874-6236
Amnart Onsa-ArdDivision of Biochemistry, School of Medical Sciences, University of Phayao, Phayao 56000, Thailand.
Jiraporn TocharusDepartment of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Rattapong SungnoonDepartment of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Rungusa PantanDepartment of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Krisana NilsuwanInternational Center of Excellence in Seafood Science and Innovation, Faculty of Agro-Industry, Prince of Songkla University, Songkhla 90110, Thailand.
Soottawat BenjakulInternational Center of Excellence in Seafood Science and Innovation, Faculty of Agro-Industry, Prince of Songkla University, Songkhla 90110, Thailand.ORCID 0000-0001-9433-3671
Chainarong TocharusDepartment of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.ORCID 0000-0003-3168-5201

Funding

National Research Council of Thailand N42A670596
6 · The paper itself

Abstract

Hydrolyzed collagen (HC) derived from salmon skin is a promising source of bioactive peptides. In this study, the vasorelaxant effects and potential mechanisms of action of HC on isolated rat thoracic aorta rings were investigated using the organ bath technique. The vasorelaxant properties of HC were evaluated using aortic rings from Wistar rats pre-contracted with phenylephrine (PE) or potassium chloride (KCl). HC induced significant vasorelaxation in both endothelium-intact and endothelium-denuded rings, indicating that its mechanism of action was independent of the endothelium and involved direct effects on vascular smooth muscle cells. The vasorelaxant effect of HC was reduced when pre-contraction was induced by tetraethylammonium chloride (TEA). However, the vasodilatory effects of HC were not significantly inhibited by all K

Indexed as

Aorta, ThoracicCollagenSalmonSkinVasodilationVasodilator Agents4-AminopyridineAnimalsCalciumEndothelium, VascularHydrolysisMaleMuscle, Smooth, VascularPotassium Channel BlockersRatsRats, Wistar4-AminopyridineCalciumCollagenPotassium Channel BlockersVasodilator Agentshydrolyzed collagenhypertensionrat aortasalmon skinvasorelaxation

Identifiers

PMID42123662
PMCPMC13163282

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.