In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
14 authors.
Abdulaziz H Al KhzemDepartment of Pharmaceutical Chemistry, College of Pharmacy, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.ORCID 0009-0004-0079-8646 S M El RayesDepartment of Chemistry, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt.ORCID 0000-0003-2667-3855 Ibrahim A I AliDepartment of Chemistry, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt.
Walid FathallaDepartment of Physical Sciences, Faculty of Engineering, Suez Canal University, Ismailia 41522, Egypt.
Mansour S AlturkiDepartment of Pharmaceutical Chemistry, College of Pharmacy, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.ORCID 0000-0001-7702-9379 Nada TawfeeqDepartment of Pharmaceutical Chemistry, College of Pharmacy, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.ORCID 0000-0002-9178-9021 Saeed M TayebPharmaceutical Sciences Department, College of Pharmacy, Umm Al-Qura University, Makkah 24381, Saudi Arabia.
Abdulelah A AlfattaniPharmaceutical Sciences Department, College of Pharmacy, Umm Al-Qura University, Makkah 24381, Saudi Arabia.ORCID 0000-0003-4596-5263 Saad M WaliPharmacology and Toxicology Department, College of Pharmacy, Umm Al-Qura University, Makkah 24342, Saudi Arabia.ORCID 0009-0006-0080-4799 Firdos A KhanDepartment of Stem Cell Biology, Institute for Research & Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.ORCID 0000-0002-6892-1530 Abdulmalik M AlqarniDepartment of Pharmaceutical Chemistry, College of Pharmacy, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.ORCID 0000-0002-6955-0313 Faheem H PottooDepartment of Pharmacology, College of Pharmacy, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.ORCID 0000-0003-2577-7505 Dania HusseinDepartment of Pharmacology, College of Pharmacy, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.
Mohamed S GomaaDepartment of Pharmaceutical Chemistry, College of Pharmacy, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia.ORCID 0000-0003-2112-9092 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Colorectal cancer (CRC) is the third most prevalent cancer globally. TASK-1, encoded by the KCNK3 gene, is emerging as a putative target in cancer; it regulates resting membrane potential, cell proliferation, and apoptosis. A series of 27 novel xanthene derivatives, modified at position 9, were synthesized via azide coupling of 2-(9H-xanthen-9-yl)acetohydrazide with selected amines and amino acids, followed by hydrazine-mediated conversion to the corresponding hydrazides. The cytotoxic activity of selected compounds (
Indexed as
AcetamidesAntineoplastic AgentsColonic NeoplasmsColorectal NeoplasmsNerve Tissue ProteinsPotassium Channels, Tandem Pore DomainApoptosisCell ProliferationHCT116 CellsHumansMolecular Docking SimulationMolecular Dynamics SimulationAcetamidesAntineoplastic AgentsNerve Tissue ProteinsPotassium Channels, Tandem Pore Domainpotassium channel subfamily K member 3apoptosiscancer therapeuticsHCT-116 cellsK2P3.1 (TASK-1)KCNK3molecular dockingpotassium channels
Identifiers
PMID42123646
PMCPMC13164145
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