Evidence map›Paper›PMID 42123637›Full record

ArticleInternational journal of molecular sciences2026

BDNF and IL-33 Dynamics in an Ultrasound Stress Model of Fibromyalgia-like Phenotypes.

Careen A Schroeter, Dmitrii Pavlov, Johannes P M de Munter, Alexei Umriukhin, Raymond Cespuglio, Maria Kuznetsova, Alexey V Deykin, Sholpan Askarova, Michael Sicker, Anna Gorlova and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Beneficial Effects of Putative Hydrogen Sulfide (HMolecules (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Careen A SchroeterPreventive & Environmental Medicine Unit, Clinic Kastanienhof, Statthalterhofweg 70, 50858 Köln-Junkersdorf, Germany.
Dmitrii PavlovHotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 1N4, Canada.
Johannes P M de MunterDepartment of Psychiatry and Neuropsychology, Maastricht University, Universiteitsinsel 50, 6229 ER Maastricht, The Netherlands.ORCID 0000-0001-7583-1464
Alexei UmriukhinDepartment of Normal Physiology, Sechenov University, 117198 Moscow, Russia.
Raymond CespuglioNeuroscience Research Center of Lyon, ENES Team, Claude-Bernard Lyon-1 University, 69675 Bron, France.
Maria KuznetsovaDepartment of Normal Physiology, Sechenov University, 117198 Moscow, Russia.
Alexey V DeykinLaboratory of Genetic Technology and Gene Editing for Biomedicine and Veterinary, National Research Belgorod State University, 308015 Belgorod, Russia.
Sholpan AskarovaDepartment of Normal Physiology, Sechenov University, 117198 Moscow, Russia.ORCID 0000-0001-6161-1671
Michael SickerRehabilitationsfachkliniken, Hochwald-Kliniken, 66709 Weiskirchen, Germany.
Anna GorlovaDepartment of Psychiatry and Neuropsychology, Maastricht University, Universiteitsinsel 50, 6229 ER Maastricht, The Netherlands.
Tatyana StrekalovaDepartment of Psychiatry and Neuropsychology, Maastricht University, Universiteitsinsel 50, 6229 ER Maastricht, The Netherlands.

Funding

EU framework Aqua-Synapse 101086453PhytoAPP EU framework 101007642Scientific state assignments FZWG, RF FZWG-2024-0003
6 · The paper itself

Abstract

Fibromyalgia, a syndrome characterized by hyperalgesia and 'negative emotionality', and major depressive disorder (MDD) demonstrate substantial overlaps in clinical, neurobiological, and therapeutic domains. Currently, treatment options for fibromyalgia remain limited; however, the epidemiology of this syndrome continues to grow worldwide. The use of animal models is indispensable for developing new treatment strategies for fibromyalgia. Meanwhile, the choice of animal paradigms is limited. Here, we used the ultrasound exposure of emotional stress on CBA, BALB/c, and C57BL/6 mouse strains to model this condition and to identify new molecular targets of fibromyalgia treatment. We exposed young male mice of three common strains to a three-week ultrasound stress (US) comprising emotionally negative and neutral frequencies of 20-25 kHz and 25-45 kHz, resulting in the development of altered pain sensitivity and signs of 'negative emotionality'. Specifically, mice were studied for timid-like/aggressive behaviors and the tail flick response. Serum levels of corticosterone, cortisol, β-Endorphin, and brain-derived neurotrophic factor (BDNF), as well as brain gene expression of interleukin-33 (

Indexed as

Brain-Derived Neurotrophic FactorFibromyalgiaInterleukin-33Stress, PsychologicalUltrasonic WavesAnimalsDisease Models, AnimalHyperalgesiaMaleMiceMice, Inbred BALB CMice, Inbred C57BLPhenotypeBdnf protein, mouseBrain-Derived Neurotrophic FactorIl33 protein, mouseInterleukin-33aggressionallodyniaanimal modelbrain-derived neurotrophic factor (BDNF)fibromyalgiainterleukin-33 (IL-33)major depressionpain sensitivityultrasound stress

Identifiers

PMID42123637
PMCPMC13163552

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.