Evidence map›Paper›PMID 42123634›Full record

ArticleInternational journal of molecular sciences2026

Exploring Neuroprotective Potential of Bioactive Compounds Obtained from Artichoke By-Products by Pressurized Liquid Extraction via Response Surface Methodology.

Edmondo Messinese, Alberto Valdés, Antonella Cavazza, Alejandro Cifuentes

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Edmondo MessineseDipartimento di Scienze Chimiche, Della Vita e della Sostenibilità Ambientale (SCVSA), Università di Parma, Parco Area delle Scienze 17/A, 43124 Parma, Italy.ORCID 0000-0001-7619-3716
Alberto ValdésFoodomics Laboratory, Institute of Food Science Research (CIAL), CSIC-UAM, Nicolas Cabrera 9, 28049 Madrid, Spain.ORCID 0000-0002-7901-5816
Antonella CavazzaDipartimento di Scienze Chimiche, Della Vita e della Sostenibilità Ambientale (SCVSA), Università di Parma, Parco Area delle Scienze 17/A, 43124 Parma, Italy.ORCID 0000-0002-2885-4839
Alejandro CifuentesFoodomics Laboratory, Institute of Food Science Research (CIAL), CSIC-UAM, Nicolas Cabrera 9, 28049 Madrid, Spain.ORCID 0000-0002-7464-0217

Funding

Ministerio de Ciencia, Innovación y Universidades PID2024-162231OA-I00
6 · The paper itself

Abstract

Artichoke by-products (ABP) represent valuable sources of bioactive compounds with relevant health benefits. In this study, a green extraction strategy based on pressurized liquid extraction (PLE) was optimized to enhance the recovery of phenolic and flavonoid compounds from ABP using a response surface methodology. Extraction temperature and solvent composition were identified as the key factors driving extraction performance. Optimal conditions using a mixture of ethyl acetate and ethanol (90/10,

Indexed as

Cynara scolymusLiquid-Liquid ExtractionNeuroprotective AgentsPlant ExtractsAcetylcholinesteraseAntioxidantsBlood-Brain BarrierButyrylcholinesteraseCholinesterase InhibitorsChromatography, High Pressure LiquidFlavonoidsLipoxygenaseMolecular Docking SimulationPhenolsSolventsTandem Mass SpectrometryAcetylcholinesteraseAntioxidantsButyrylcholinesteraseCholinesterase InhibitorsFlavonoidsLipoxygenaseNeuroprotective AgentsPhenolsPlant ExtractsSolventsagro-food by-productsblood–brain barriercaffeoylquinic acidsgreen extractionneuroprotective activitypressurized liquid extraction

Identifiers

PMID42123634
PMCPMC13164496

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.