Evidence map›Paper›PMID 42123573›Full record

ReviewInternational journal of molecular sciences2026

Molecular Mechanisms of Negative Effect of Systemic Lupus Erythematosus on Oogenesis and Meiotic Processes in Oocytes.

Stefka Delimitreva, Ana Blagoeva, Irina Chakarova

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Stefka DelimitrevaDepartment of Biology, Medical University of Sofia, 2 Zdrave Street, 1431 Sofia, Bulgaria.ORCID 0000-0001-8847-4654
Ana BlagoevaDepartment of Biology, Medical University of Sofia, 2 Zdrave Street, 1431 Sofia, Bulgaria.
Irina ChakarovaDepartment of Biology, Medical University of Sofia, 2 Zdrave Street, 1431 Sofia, Bulgaria.ORCID 0000-0002-8008-9812

Funding

Medical University of Sofia D-153/2025
6 · The paper itself

Abstract

Systemic lupus erythematosus is an autoimmune disease that mainly affects women of reproductive age. Its pathological manifestations directly and indirectly negatively affect the ovarian reserve, the quality of oocytes, and the precise mechanisms of meiosis. This review presents the molecular mechanisms by which lupus damages ovarian tissue and meiosis in oocytes. The role of chronic inflammation, impaired hormonal levels, and the presence of specific autoantibodies are considered. The available data on how oocyte structures (meiotic spindle, actin cytoskeleton, membrane organelles and chromatin) are damaged by lupus symptoms are summarized.

Indexed as

Lupus Erythematosus, SystemicMeiosisOocytesOogenesisAnimalsFemaleHumansmeiosisoocyteoogenesissystemic lupus erythematosus (SLE)

Identifiers

PMID42123573
PMCPMC13163541

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.