Evidence map›Paper›PMID 42123558›Full record

ReviewInternational journal of molecular sciences2026

From Epigenetic Regulation to Protein Degradation: Emerging Strategies for Anti-Infective Drug Discovery.

Andressa Francielli Bonjorno, Diogo Boreski, Ana Luísa Rodriguez Gini, Pamela Souza Tada da Cunha, Jhonnathan Alves Moura, Chung Man Chin, Cauê Benito Scarim, Jean Leandro Dos Santos

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Andressa Francielli BonjornoSão Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara 14800-903, Brazil.ORCID 0000-0002-8666-008X
Diogo BoreskiSão Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara 14800-903, Brazil.ORCID 0000-0001-9323-4735
Ana Luísa Rodriguez GiniSão Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara 14800-903, Brazil.ORCID 0000-0003-2643-810X
Pamela Souza Tada da CunhaSão Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara 14800-903, Brazil.ORCID 0000-0002-3019-5393
Jhonnathan Alves MouraSão Paulo State University (UNESP), Institute of Chemistry, Araraquara 14800-060, Brazil.ORCID 0009-0009-3696-1085
Chung Man ChinSão Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara 14800-903, Brazil.ORCID 0000-0003-4141-0455
Cauê Benito ScarimSão Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara 14800-903, Brazil.ORCID 0000-0002-2540-6395
Jean Leandro Dos SantosSão Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara 14800-903, Brazil.ORCID 0000-0002-2460-2829

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior 001Coordenação de Aperfeicoamento de Pessoal de Nível Superior 88887.103208/2025-00Coordenação de Aperfeicoamento de Pessoal de Nível Superior 88887.940588/2024-00Fundação de Amparo à Pesquisa do Estado de São Paulo 2024/03928-9Fundação de Amparo à Pesquisa do Estado de São Paulo 2024/18020-2Fundação de Amparo à Pesquisa do Estado de São Paulo 2025/03878-4National Council for Scientific and Technological Development 302433/2023-6National Council for Scientific and Technological Development 401319/2025-3
6 · The paper itself

Abstract

Infectious diseases remain a major global health challenge, driven by antimicrobial resistance, pathogen persistence, and the limited integration of mechanistically innovative therapeutic approaches. Emerging evidence indicates that epigenetic regulation is fundamental to host-pathogen interactions, influencing transcriptional programmes associated with virulence, immune evasion, stress adaptation, and phenotypic plasticity. In organisms such as bacteria, parasites, and intracellular pathogens, including

Indexed as

Anti-Infective AgentsDrug DiscoveryEpigenesis, GeneticProteolysisAnimalsHost-Directed TherapyHost-Pathogen InteractionsHumansProteolysis Targeting ChimeraAnti-Infective AgentsProteolysis Targeting ChimeraATTECAUTACBacPROTAChost–pathogenLYTACPROTAC

Identifiers

PMID42123558
PMCPMC13163363

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.