Evidence map›Paper›PMID 42123548›Full record

ReviewInternational journal of molecular sciences2026

Genetic Polymorphisms in Systemic Lupus Erythematosus and Their Clinical Implications: A Narrative Review.

Audrey Matilda Egan, Nor Adzimah Johdi, Elena Aisha Azizan, Rozita Mohd, Sakthiswary Rajalingham, Syahrul Sazliyana Shaharir, Mohamed Afiq Hidayat Zailani

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Audrey Matilda EganDepartment of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Cheras 56000, Kuala Lumpur, Malaysia.ORCID 0009-0000-2385-0647
Nor Adzimah JohdiUKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, Cheras 56000, Kuala Lumpur, Malaysia.ORCID 0000-0003-1953-112X
Elena Aisha AzizanDepartment of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Cheras 56000, Kuala Lumpur, Malaysia.ORCID 0000-0002-5549-4242
Rozita MohdDepartment of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Cheras 56000, Kuala Lumpur, Malaysia.
Sakthiswary RajalinghamDepartment of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Cheras 56000, Kuala Lumpur, Malaysia.
Syahrul Sazliyana ShaharirDepartment of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Cheras 56000, Kuala Lumpur, Malaysia.
Mohamed Afiq Hidayat ZailaniDepartment of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Cheras 56000, Kuala Lumpur, Malaysia.ORCID 0000-0002-0768-7605

Funding

Ministry of Higher Education Malaysia, Fundamental Research Grant Scheme (FRGS) FRGS/1/2023/SKK01/UKM/02/1
6 · The paper itself

Abstract

Systemic lupus erythematosus (SLE) is a polygenic autoimmune disorder where genetic diversity drives significant clinical heterogeneity. This review summarizes the current understanding of the roles of genetic polymorphisms in immunological dysregulation, organ-specific manifestations and therapeutic response heterogeneity in individuals with SLE. The literature was obtained from PubMed, EBSCOhost, Web of Science and Scopus. The narrative review comprised 60 publications published within the last 12 years. The research consistently identifies the major histocompatibility complex (MHC) region as the most significant genetic risk factor for the onset of autoimmunity. Genetic variants in

Indexed as

Genetic Predisposition to DiseaseLupus Erythematosus, SystemicPolymorphism, GeneticHumansInterferon Regulatory FactorsSTAT4 Transcription FactorToll-Like Receptor 7Interferon Regulatory FactorsIRF5 protein, humanSTAT4 protein, humanSTAT4 Transcription FactorToll-Like Receptor 7autoimmune diseasebiomarkersgenetic polymorphismsmolecular geneticssingle nucleotide polymorphismsystemic lupus erythematosustargeted therapies

Identifiers

PMID42123548
PMCPMC13164053

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.