ArticleInternational journal of molecular sciences2026
Modulation of ESKAPE Bacteria Properties by NK-92 and NK-92-Derived LEVs: First Insights.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
ESKAPE pathogens represent a critical threat to global health. This challenge necessitates the development of novel antibacterial strategies. We investigated the antimicrobial potential of NK-92 cells and their derived large extracellular vesicles using flow cytometry, ELISA, confocal microscopy and microbiology assays. Here, we show that both NK-92 cells and NK-92-derived LEVs can interact with bacteria, as confirmed by confocal microscopy and flow cytometry. This interaction is associated with inhibition of colony formation. A possible mechanism can involve defensin-α1 secreted by NK-92 and packed in their LEVs. NK-92-derived LEVs can modulate
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