ArticleInternational journal of molecular sciences2026
Serum Metabolomic Profiling Across Five Oligoclonal Band (OCB) Patterns: A Targeted
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Cerebrospinal fluid (CSF) oligoclonal band (OCB) analysis remains central to the diagnostic evaluation of neuroinflammatory diseases of the central nervous system (CNS), as it reflects intrathecal immunoglobulin synthesis. However, its reliance on lumbar puncture limits its applicability for screening and repeated longitudinal assessment. Serum metabolomics offers a minimally invasive strategy to explore peripheral biochemical correlates of central immune activity. Building on previous binary OCB comparisons, the present study extends serum metabolomic analysis to encompass all five classical OCB patterns, thereby capturing a broader immunological spectrum. A total of 92 adults undergoing diagnostic evaluation for suspected CNS inflammatory disorders were retrospectively stratified according to OCB type (Types 1-5). Serum samples were analysed using targeted
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