Evidence map›Paper›PMID 42123478›Full record

ArticleInternational journal of molecular sciences2026

Amyloid Precursor Protein Abnormalities Destabilize Membrane Ferroportin: A Novel Mechanism Underlying Early Brain Pathologies and Memory Impairment in Alzheimer's Disease.

Yifan Xiao, Wenli Huang, Lingyan Chen, Rufeng Huang, Yuhui Guo, Wei Liu, Xiaochuan Wang, Jianzhi Wang, Jian Bao, Xiji Shu

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yifan XiaoHubei Key Laboratory of Cognitive and Affective Disorders, School of Medicine, Jianghan University, Wuhan 430056, China.ORCID 0000-0001-5049-0288
Wenli HuangHubei Key Laboratory of Cognitive and Affective Disorders, School of Medicine, Jianghan University, Wuhan 430056, China.ORCID 0009-0006-5609-4247
Lingyan ChenHubei Key Laboratory of Cognitive and Affective Disorders, School of Medicine, Jianghan University, Wuhan 430056, China.
Rufeng HuangHubei Key Laboratory of Cognitive and Affective Disorders, School of Medicine, Jianghan University, Wuhan 430056, China.
Yuhui GuoHubei Key Laboratory of Cognitive and Affective Disorders, School of Medicine, Jianghan University, Wuhan 430056, China.
Wei LiuHubei Key Laboratory of Cognitive and Affective Disorders, School of Medicine, Jianghan University, Wuhan 430056, China.ORCID 0000-0002-9033-2142
Xiaochuan WangHubei Key Laboratory of Cognitive and Affective Disorders, School of Medicine, Jianghan University, Wuhan 430056, China.ORCID 0000-0001-8207-0042
Jianzhi WangHubei Key Laboratory of Cognitive and Affective Disorders, School of Medicine, Jianghan University, Wuhan 430056, China.
Jian BaoHubei Key Laboratory of Cognitive and Affective Disorders, School of Medicine, Jianghan University, Wuhan 430056, China.ORCID 0000-0003-2869-8415
Xiji ShuHubei Key Laboratory of Cognitive and Affective Disorders, School of Medicine, Jianghan University, Wuhan 430056, China.ORCID 0000-0002-7415-6230

Funding

Intelligent Cancer Prevention and Control Platform Development and Industrialization No. 2024HBQZYCSB046National Natural Science Foundation of China 82001281National Natural Science Foundation of China 82371195
6 · The paper itself

Abstract

Alzheimer's disease (AD) research has primarily focused on amyloid beta (Aβ) and

Indexed as

Alzheimer DiseaseAmyloid beta-Protein PrecursorBrainCation Transport ProteinsMemory DisordersAmyloid beta-PeptidesAnimalsCell MembraneDisease Models, AnimalFerroportinFerroptosisHumansMiceMice, TransgenicMutationAmyloid beta-PeptidesAmyloid beta-Protein PrecursorCation Transport ProteinsFerroportinAlzheimer’s disease (AD)amyloid precursor protein (APP)ferroportin (FPN)ferroptosismemory impairment

Identifiers

PMID42123478
PMCPMC13164331

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.