Evidence map›Paper›PMID 42123475›Full record

ArticleInternational journal of molecular sciences2026

High-Fat, High-Cholesterol Diet Influence on Matrix Metalloproteinases and Transcription of c-Jun and TGF-βin Cardiac Muscle of ApoE (-/-) Mice.

Michał Kowara, Katarzyna Czarzasta, Michał Jędrzejewski, Łukasz Koperski, Agnieszka Segiet-Święcicka, Robert Wrzesień, Marek Kuch, Agnieszka Cudnoch-Jędrzejewska

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michał KowaraDepartment of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Banacha 1b, 02-097 Warsaw, Poland.ORCID 0000-0003-3689-4192
Katarzyna CzarzastaDepartment of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Banacha 1b, 02-097 Warsaw, Poland.ORCID 0000-0002-9836-9409
Michał JędrzejewskiKrajmed Medical Center, Bacha 2, 02-743 Warsaw, Poland.
Łukasz KoperskiDepartment of Pathology, Medical University of Warsaw, Pawińskiego 7, 02-106 Warsaw, Poland.
Agnieszka Segiet-ŚwięcickaDepartment of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Banacha 1b, 02-097 Warsaw, Poland.
Robert WrzesieńCentral Laboratory of Experimental Animals, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Banacha 1b, 02-097 Warsaw, Poland.ORCID 0000-0002-2023-7633
Marek KuchChair and Department of Cardiology, Hypertension and Internal Medicine, Medical University of Warsaw, Kondratowicza 8, 03-242 Warsaw, Poland.ORCID 0000-0001-7622-9758
Agnieszka Cudnoch-JędrzejewskaDepartment of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Banacha 1b, 02-097 Warsaw, Poland.

Funding

Medical University of Warsaw 1MA/PM2/17
6 · The paper itself

Abstract

A high-fat, high-cholesterol diet (HFHCD) has a lipotoxic effect on the heart. It not only leads to the development of atherosclerosis but also influences the extracellular matrix within the heart. The aim of the study was to investigate the effect of HFHCD on matrix metalloproteinases MMP-2, MMP-9, MMP-13, and MMP-14 expression in both the cardiac tissue and plasma of ApoE (-/-) mice and on mRNA expression of c-Jun and TGF-β in the cardiac tissue of both ApoE (-/-) mice and wild-type C57BL/6J mice. The study was carried out on two groups of ApoE (-/-) mice: (1) mice from 10 weeks of age that were kept on a HFHCD (

Indexed as

Apolipoproteins ECholesterol, DietaryDiet, High-FatMatrix MetalloproteinasesMyocardiumProto-Oncogene Proteins c-junTranscription, GeneticTransforming Growth Factor betaAnimalsMaleMiceMice, Inbred C57BLMice, KnockoutRNA, MessengerApolipoproteins ECholesterol, DietaryMatrix MetalloproteinasesProto-Oncogene Proteins c-junRNA, MessengerTransforming Growth Factor betaApoE (-/-) miceatherosclerosishigh-fat, high-cholesterol dietmatrix metalloproteinasesmRNA

Identifiers

PMID42123475
PMCPMC13163240

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.