Evidence map›Paper›PMID 42123468›Full record

ArticleInternational journal of molecular sciences2026

Dual Targeting of EZH2 and LSD1 Suppresses Hepatocellular Carcinoma via Disruption of Sonic Hedgehog Signaling.

HongDuck Yun, Ponmari Guruvaiya, Olena Levurdiak, Alexei G Basnakian, Marjan Boerma, Stephen Safe, KyoungHyun Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

HongDuck YunDepartment of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72225, USA.ORCID 0000-0002-9263-5606
Ponmari GuruvaiyaDepartment of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72225, USA.ORCID 0009-0008-3847-0602
Olena LevurdiakDepartment of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72225, USA.
Alexei G BasnakianDepartment of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72225, USA.ORCID 0000-0002-9115-6283
Marjan BoermaDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72225, USA.ORCID 0000-0003-2249-5203
Stephen SafeDepartment of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-2115-3060
KyoungHyun KimDepartment of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72225, USA.ORCID 0000-0002-7240-2768

Funding

Arkansas Bioscience Institute AWD-102724BLRD VA I01 BX002425BLRD VA IK6 BX006184NIGMS NIH HHS P20-GM109005Winthrop P. Rockefeller Cancer Institute F208
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is a highly aggressive malignancy with poor prognosis and limited therapeutic options. Although epigenetic dysregulation is a hallmark of HCC, rational combinatorial targeting strategies remain incompletely defined. Here, we identify cooperative oncogenic functions of the chromatin modifiers enhancer of zeste homolog 2 (

Indexed as

Carcinoma, HepatocellularEnhancer of Zeste Homolog 2 ProteinHedgehog ProteinsHistone DemethylasesLiver NeoplasmsSignal TransductionAnimalsApoptosisCell Line, TumorCell MovementCell ProliferationGene Expression Regulation, NeoplasticHumansHydrazinesIndolesPyridonesEnhancer of Zeste Homolog 2 ProteinEZH2 protein, humanGSK-2816126Hedgehog ProteinsHistone DemethylasesHydrazinesIndolesKDM1A protein, humanPyridonesSHH protein, humanSP2509SulfonamidesThiophenesZinc Finger Protein GLI1dual inhibitionEZH2GLI1hepatocellular carcinomaLSD1SHHSTAT3

Identifiers

PMID42123468
PMCPMC13163952

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.