Evidence map›Paper›PMID 42123462›Full record

ArticleInternational journal of molecular sciences2026

Metabotropic Glutamate Receptor 3 Expression During Liver Disease Progression: Association with Inflammation and Cell Viability in Hepatocellular Carcinoma.

Ana Cristina García-Gaytán, Andy Hernández-Abrego, Dalia De Ita-Pérez, Ericka de Los Ríos-Arellano, Emanuel Gámez, Mauricio Díaz-Muñoz, Isabel Méndez

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ana Cristina García-GaytánDepartamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM), Campus UNAM-Juriquilla, Juriquilla 76230, Querétaro, Mexico.
Andy Hernández-AbregoDepartamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM), Campus UNAM-Juriquilla, Juriquilla 76230, Querétaro, Mexico.ORCID 0009-0002-6165-8095
Dalia De Ita-PérezDepartamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM), Campus UNAM-Juriquilla, Juriquilla 76230, Querétaro, Mexico.
Ericka de Los Ríos-ArellanoDepartamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM), Campus UNAM-Juriquilla, Juriquilla 76230, Querétaro, Mexico.ORCID 0000-0001-9235-5199
Emanuel GámezCentro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara 44340, Jalisco, Mexico.ORCID 0009-0007-2170-6861
Mauricio Díaz-MuñozDepartamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM), Campus UNAM-Juriquilla, Juriquilla 76230, Querétaro, Mexico.ORCID 0000-0002-9019-8246
Isabel MéndezDepartamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM), Campus UNAM-Juriquilla, Juriquilla 76230, Querétaro, Mexico.ORCID 0000-0002-6731-9468

Funding

DGAPA-PAPIIT, UNAM IN206418DGAPA-PAPIIT, UNAM IN222821DGAPA-PAPIIT, UNAM N223124SECIHTI CF-2023-I-768
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is the most common type of liver cancer that is mostly preceded by cirrhosis, with a high mortality rate. Therefore, diagnosis is critical in the early stages. In this study, we explored the liver expression of metabotropic glutamate receptor 3 (mGluR3), a group II mGluR, during the progression from fibrosis to cirrhosis and, ultimately, to HCC induced by diethylnitrosamine (DEN) in rats. We found that mRNA expression of mGluR3 (

Indexed as

Carcinoma, HepatocellularInflammationLiver NeoplasmsReceptors, Metabotropic GlutamateAnimalsCell SurvivalDisease ProgressionGene Expression Regulation, NeoplasticGlutamic AcidHepatocytesHep G2 CellsHumansLiver CirrhosisMaleRatsTransforming Growth Factor betaGlutamic Acidmetabotropic glutamate receptor 3Receptors, Metabotropic GlutamateTransforming Growth Factor betacirrhosisfibrosisglutamatehepatocellular carcinomainflammationmetabotropic glutamate receptor type 3

Identifiers

PMID42123462
PMCPMC13164193

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.