Evidence map›Paper›PMID 42123447›Full record

ReviewInternational journal of molecular sciences2026

Advances in the Role of the CD40-CD154 Pathway in the Pathogenesis of Diabetic Retinopathy.

Carlos S Subauste

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Carlos S SubausteDivision of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.

Funding

Autophagy and Ocular ToxoplasmosisR01EY018341 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI SUBAUSTE, CARLOS S · 2009 to 2024
$5.0M
Regulation of retinopathiesR01EY019250 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI SUBAUSTE, CARLOS S · 2010 to 2022
$3.7M
Falk Medical Research Trust Catalyst Award - SubausteNEI NIH HHS P30 NEI EY011373NEI NIH HHS R01 EY018341NEI NIH HHS R01 EY019250
6 · The paper itself

Abstract

Diabetic retinopathy is one of the most important complications of diabetes. It is a leading cause of visual loss in the world. While adequate control of hyperglycemia, hypertension and hyperlipidemia can decrease the prevalence of diabetic retinopathy, 60% of patients with type 2 diabetes develop this complication whereas it is estimated that most patients with type 1 diabetes will develop diabetic retinopathy. Upregulation of various pro-inflammatory molecules and vascular endothelial growth factor (VEGF) play a central role in the pathogenesis of the disease. Here we review the role of CD40 as an upstream inducer of these abnormalities and the development of diabetic retinopathy.

Indexed as

CD40 AntigensCD40 LigandDiabetic RetinopathySignal TransductionAnimalsHumansVascular Endothelial Growth Factor ACD40 AntigensCD40 LigandVascular Endothelial Growth Factor Acytokinesendothelial cellsinflammationMüller cellsVEGF

Identifiers

PMID42123447
PMCPMC13163484

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.