Evidence map›Paper›PMID 42123441›Full record

ArticleInternational journal of molecular sciences2026

Activity and Biocompatibility Evaluation of Enzybiotic Compositions Formulated with

Arina A Klimova, Ekaterina A Trusova, Elizaveta A Akoulina, Nataliia P Antonova, Andrei A Dudun, Michail Yu Orlov, Marina Yu Kochevalina, Vera V Voinova, Anton P Bonartsev, Daria V Vasina

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Arina A KlimovaN.F. Gamaleya National Research Centre for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia.ORCID 0009-0003-4371-5639
Ekaterina A TrusovaFaculty of Biology, MSU-BIT Shenzhen University, Shenzhen 518115, China.
Elizaveta A AkoulinaFaculty of Biology, MSU-BIT Shenzhen University, Shenzhen 518115, China.ORCID 0000-0002-2560-624X
Nataliia P AntonovaN.F. Gamaleya National Research Centre for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia.ORCID 0000-0001-7025-8056
Andrei A DudunN.F. Gamaleya National Research Centre for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia.ORCID 0000-0002-3307-7923
Michail Yu OrlovFaculty of Biology, M.V. Lomonosov Moscow State University, 119234 Moscow, Russia.ORCID 0009-0000-1422-9648
Marina Yu KochevalinaFaculty of Biology, M.V. Lomonosov Moscow State University, 119234 Moscow, Russia.ORCID 0000-0002-5870-7952
Vera V VoinovaFaculty of Biology, M.V. Lomonosov Moscow State University, 119234 Moscow, Russia.ORCID 0000-0002-0253-6461
Anton P BonartsevFaculty of Biology, M.V. Lomonosov Moscow State University, 119234 Moscow, Russia.ORCID 0000-0001-5894-9524
Daria V VasinaN.F. Gamaleya National Research Centre for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia.ORCID 0000-0003-1965-0700

Funding

Russian Science Foundation 23-74-10027
6 · The paper itself

Abstract

Due to their availability and environmental friendliness, alginate polymers are widely used in pharmaceuticals and cosmetics. The most common type of alginate is derived from seaweed and is used to develop topical dosage forms, among other things. However, variability in the seaweed material can lead to instability in the physicochemical parameters. Biotechnologically produced alginate minimizes this drawback through controlled synthesis. However, unlike algal alginates, the safety profile of such polymers has not been well studied. When developing dosage forms intended for wound surfaces, safety is of primary importance. In this study, we developed enzybiotic compositions based on bacterial alginate as an excipient and a novel recombinant modified endolysin, LysSi3-LK, as an antibacterial agent, and assessed their antibacterial properties and safety profile. The study included an

Indexed as

AlginatesAnti-Bacterial AgentsBiocompatible MaterialsEndopeptidasesAdministration, TopicalCell ProliferationHaCaT CellsHumansHydrogelsRecombinant ProteinsAlginatesAnti-Bacterial AgentsBiocompatible MaterialsendolysinEndopeptidasesHydrogelsRecombinant Proteinsbacterial alginatehydrogelrecombinant endolysinsafetytopical gelswound material

Identifiers

PMID42123441
PMCPMC13163262

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.