Evidence map›Paper›PMID 42123403›Full record

ArticleInternational journal of molecular sciences2026

Gestational and Lactational Atrazine Exposure Potentially Mediates Behavioral and Dopaminergic Alterations in Rat Offspring: Insights into Nurr1-Related ceRNA Regulation.

Yongjie Ma, Tianao Sun, Minglian Pan, Zhanyue Zheng, Jingxia Wei, Xinyu Yuan, Jinhao Wan, Yingjie Zhou, Yan Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yongjie MaSchool of Public Health, Guilin Medical University, Guilin 541199, China.
Tianao SunSchool of Public Health, Guilin Medical University, Guilin 541199, China.
Minglian PanSchool of Public Health, Guilin Medical University, Guilin 541199, China.
Zhanyue ZhengSchool of Public Health, Guilin Medical University, Guilin 541199, China.
Jingxia WeiSchool of Public Health, Guilin Medical University, Guilin 541199, China.
Xinyu YuanSchool of Public Health, Guilin Medical University, Guilin 541199, China.
Jinhao WanSchool of Public Health, Guilin Medical University, Guilin 541199, China.
Yingjie ZhouSchool of Public Health, Guilin Medical University, Guilin 541199, China.
Yan SunSchool of Public Health, Guilin Medical University, Guilin 541199, China.

Funding

Graduate Research Program of Guilin Medical University GYYK2025020Guang Xi Natural Science Foundation General Program 2023GXNSFAA026035
6 · The paper itself

Abstract

This study aimed to investigate the molecular mechanisms underlying dopaminergic injury induced by gestational and lactational atrazine (ATR) exposure in rat offspring, with a particular focus on non-coding RNA-mediated regulation. Pregnant rats were exposed to ATR during gestation and lactation. Offspring underwent behavioral testing at postnatal day 21 (PND21) and were sacrificed for midbrain tissue collection at PND28. Behavioral alterations, histopathological changes in the substantia nigra, and dopaminergic marker expression were assessed to evaluate ATR-induced neurotoxicity. Whole-transcriptome sequencing was then performed to identify differentially expressed mRNAs, miRNAs, and lncRNAs, followed by co-expression, protein-protein interaction, and competing endogenous RNA (ceRNA) network analyses. Key targets were validated by qRT-PCR. Candidate molecules identified from transcriptomic and ceRNA analyses were further examined in an ATR-induced neurotoxicity model established in RA-differentiated

Indexed as

AtrazineBehavior, AnimalDopamineDopaminergic NeuronsNuclear Receptor Subfamily 4, Group A, Member 2Prenatal Exposure Delayed EffectsAnimalsFemaleGene Expression ProfilingGene Expression RegulationHerbicidesLactationMaleMaternal ExposureMicroRNAsPregnancyAtrazineDopamineHerbicidesMicroRNAsNr4a2 protein, ratNuclear Receptor Subfamily 4, Group A, Member 2RNA, Competitive EndogenousatrazineceRNA networkdopaminergic neuronsneuroinflammationNurr1Parkinson’s disease

Identifiers

PMID42123403
PMCPMC13163254

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.