Evidence map›Paper›PMID 42123402›Full record

ArticleInternational journal of molecular sciences2026

Liv-52 Attenuates Erlotinib-Induced Liver Injury via Modulation of Oxidative Stress, Inflammation, and Apoptosis in Rats.

Seval Bulut, Durdu Altuner, Bahadir Suleyman, Renad Mammadov, Mustafa Ozkaraca, Ali Gungor, Mehmet Kuzucu, Engin Hendem, Halis Suleyman

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Seval BulutDepartment of Pharmacology, Faculty of Medicine, Erzincan Binali Yıldırım University, Erzincan 24100, Turkey.ORCID 0000-0003-4992-1241
Durdu AltunerDepartment of Pharmacology, Faculty of Medicine, Erzincan Binali Yıldırım University, Erzincan 24100, Turkey.
Bahadir SuleymanDepartment of Pharmacology, Faculty of Medicine, Erzincan Binali Yıldırım University, Erzincan 24100, Turkey.ORCID 0000-0001-5795-3177
Renad MammadovDepartment of Pharmacology, Faculty of Medicine, Erzincan Binali Yıldırım University, Erzincan 24100, Turkey.
Mustafa OzkaracaDepartment of Pathology, Faculty of Veterinary Medicine, Sivas Cumhuriyet University, Sivas 58070, Turkey.ORCID 0000-0002-6359-6249
Ali GungorLaboratory Technician and Veterinary Health Program, Vocational School of Health Services, Osmaniye Korkut Ata University, Osmaniye 80000, Turkey.ORCID 0009-0008-7985-0986
Mehmet KuzucuDepartment of Molecular Biology, Faculty of Arts and Sciences, Erzincan Binali Yıldırım University, Erzincan 24100, Turkey.ORCID 0000-0002-7786-7687
Engin HendemDepartment of Medical Oncology, Mengucek Gazi Education and Research Hospital, Erzincan Binali Yıldırım University, Erzincan 24100, Turkey.ORCID 0000-0001-6970-4733
Halis SuleymanDepartment of Pharmacology, Faculty of Medicine, Erzincan Binali Yıldırım University, Erzincan 24100, Turkey.ORCID 0000-0002-9239-4099

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), is widely used in cancer therapy; however, hepatotoxicity limits its clinical use. This study investigated the protective effects of Liv-52, a polyherbal hepatoprotective formulation, against erlotinib-induced hepatotoxicity in rats and compared its efficacy with melatonin. The animals (

Indexed as

ApoptosisChemical and Drug Induced Liver InjuryErlotinib HydrochlorideInflammationOxidative StressPlant ExtractsAnimalsAntioxidantsLiverMaleMelatoninRatsRats, WistarAntioxidantsErlotinib HydrochlorideMelatoninPlant ExtractsantioxidantapoptosiserlotinibinflammationLiv-52melatonin

Identifiers

PMID42123402
PMCPMC13163866

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.