Evidence map›Paper›PMID 42123347›Full record

ArticleInternational journal of molecular sciences2026

Gut-Heart Axis: Microbiome Involvement in Wild-Type Transthyretin Amyloidosis.

Itzel Ivonn López-Tenorio, Luis Alejandro Constantino-Jonapa, Samuel Jaimez-Alvarado, Fernando Hernández-Quiroz, Esteban Jorge-Galarza, Alma Reyna Escalona-Montaño, Amedeo Amedei, Rodrigo Soria-García, Enrique Alexander Berrios-Barcenas, María Magdalena Aguirre-García

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Itzel Ivonn López-TenorioUnidad de Investigación UNAM-INC, División de Investigación, Facultad de Medicina UNAM, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico.ORCID 0009-0003-1477-9780
Luis Alejandro Constantino-JonapaUnidad de Investigación UNAM-INC, División de Investigación, Facultad de Medicina UNAM, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico.ORCID 0000-0003-0773-2581
Samuel Jaimez-AlvaradoUnidad de Investigación UNAM-INC, División de Investigación, Facultad de Medicina UNAM, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico.ORCID 0009-0001-5095-4465
Fernando Hernández-QuirozUnidad de Investigación UNAM-INC, División de Investigación, Facultad de Medicina UNAM, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico.
Esteban Jorge-GalarzaDepartment of Outpatients Care, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico.ORCID 0000-0002-7748-4678
Alma Reyna Escalona-MontañoUnidad de Investigación UNAM-INC, División de Investigación, Facultad de Medicina UNAM, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico.ORCID 0000-0002-0060-2939
Amedeo AmedeiDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.ORCID 0000-0002-6797-9343
Rodrigo Soria-GarcíaDepartment of Outpatients Care, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico.
Enrique Alexander Berrios-BarcenasDepartment of Outpatients Care, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico.
María Magdalena Aguirre-GarcíaUnidad de Investigación UNAM-INC, División de Investigación, Facultad de Medicina UNAM, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico.ORCID 0000-0001-8696-9995

Funding

CONAHCYT CBF2023-2024-734UNAM-DGAPA-PAPIIT IN212422, IN219025
6 · The paper itself

Abstract

Cardiac amyloidosis is a rare and progressive condition characterized by the extracellular deposition of amyloid fibrils in multiple organs. Wild-type transthyretin amyloidosis (ATTR-wt) is the most common type affecting subjects above 60 years old. Recent and growing evidence suggests a potential link between GM and cardiac amyloidosis. In this scenario, the aim of the present study is to characterize the gut microbiota (GM), related metabolites and inflammatory biomarkers in ATTR-wt patients. In the ATTR patients we identified

Indexed as

Amyloid Neuropathies, FamilialGastrointestinal MicrobiomeAgedBiomarkersDysbiosisFemaleHumansMaleMiddle AgedBiomarkerscardiac amyloidosiscardiovascular diseasecytokinesfree fatty acidsgut microbiomelipopolysaccharidetransthyretintransthyretin amyloidosis

Identifiers

PMID42123347
PMCPMC13164311

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.