ArticleInternational journal of molecular sciences2026
Preparative Separation of Antioxidants from Sea Buckthorn and Its Antioxidant Activity In Vitro via Endothelial Function Regulation.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Sea buckthorn, a homologue of medicine and food, contains a host of bioactives that can prevent many diseases, especially cardiovascular diseases. The association between oxidative stress (OS) and cardiovascular diseases (CVDs) has been well-established, with OS ultimately leading to CVDs through lipid peroxidation and other mechanisms. In this study, antioxidant components were isolated from sea buckthorn by polyamide medium-pressure chromatography coupled with an HPLC-DPPH activity screening system. Two potential compounds were isolated and identified as Tetrahydroharmol and Isorhamnetin3-O-(6-O-E-sinapoyl)-β-D-glucopyranosyl-(1-2)-β-D-glucopyranoside-7-O-α-L-rhamnopyranoside. Molecular docking technology was used to explore the binding ability of two antioxidant active components to target proteins (LDH, SOD, Nrf2, iNOS, and eNOS). In addition, the antioxidant capacity was determined by EA.hy926 human umbilical vein endothelial fusion cell experiments. The results demonstrate the efficacy of this method for isolating high-purity antioxidants from sea buckthorn. These two activity compounds exhibit potential effects against cardiovascular diseases through antioxidant mechanisms.
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