Evidence map›Paper›PMID 42123330›Full record

ArticleInternational journal of molecular sciences2026

Coumarin-Thiourea Hybrids: Structural Features Governing CA Inhibition and Antiproliferative Effects.

Alma Fuentes-Aguilar, Rebecca Colombo, Aday González-Bakker, Adrián Puerta, Penélope Merino-Montiel, Sara Montiel-Smith, José L Vega-Báez, Simone Giovannuzzi, Alessio Nocentini, José G Fernández-Bolaños and 3 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Probing novel azole-sulfonamide urea/thiourea conjugates as multitarget inhibitors of AChE and hCAs (I and II): synthesis, in vitro, and in silico studies.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alma Fuentes-AguilarDepartamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Apartado 1203, E-41071 Seville, Spain.
Rebecca ColomboDepartamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Apartado 1203, E-41071 Seville, Spain.
Aday González-BakkerBioLab, Instituto Universitario de Bio-Orgánica "Antonio González" (IUBO-AG), Universidad de La Laguna, c/Astrofísico Francisco Sánchez 2, E-38206 La Laguna, Spain.ORCID 0000-0002-9792-5194
Adrián PuertaBioLab, Instituto Universitario de Bio-Orgánica "Antonio González" (IUBO-AG), Universidad de La Laguna, c/Astrofísico Francisco Sánchez 2, E-38206 La Laguna, Spain.ORCID 0000-0002-7975-1960
Penélope Merino-MontielFacultad de Ciencias Químicas, Ciudad Universitaria, Benemérita Universidad Autónoma de Puebla, Puebla 72570, Mexico.ORCID 0000-0003-1376-9671
Sara Montiel-SmithFacultad de Ciencias Químicas, Ciudad Universitaria, Benemérita Universidad Autónoma de Puebla, Puebla 72570, Mexico.ORCID 0000-0002-3080-9252
José L Vega-BáezFacultad de Ciencias Químicas, Ciudad Universitaria, Benemérita Universidad Autónoma de Puebla, Puebla 72570, Mexico.
Simone GiovannuzziNEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, University of Florence, 50019 Florence, Italy.ORCID 0000-0002-0669-7481
Alessio NocentiniNEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, University of Florence, 50019 Florence, Italy.ORCID 0000-0003-3342-702X
José G Fernández-BolañosDepartamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Apartado 1203, E-41071 Seville, Spain.
Claudiu T SupuranNEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, University of Florence, 50019 Florence, Italy.ORCID 0000-0003-4262-0323
José M PadrónBioLab, Instituto Universitario de Bio-Orgánica "Antonio González" (IUBO-AG), Universidad de La Laguna, c/Astrofísico Francisco Sánchez 2, E-38206 La Laguna, Spain.ORCID 0000-0001-6268-6552
Óscar LópezDepartamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Apartado 1203, E-41071 Seville, Spain.

Funding

Junta de Andalucía FQM-134Ministerio de Ciencia, Innovación y Universidades PID2021-123059OB-I00Ministerio de Ciencia, Innovación y Universidades PID2023-147401OB-I00
6 · The paper itself

Abstract

Selective inhibition of the tumour-associated carbonic anhydrase (CA) isoforms IX and XII, which are overexpressed in hypoxic tumours, has emerged as a promising strategy for the development of novel anticancer agents. Among the diverse CA inhibitors reported to date, coumarins have attracted particular attention. These chromenone derivatives, widely distributed in phytochemicals, display a broad range of biological activities and are known to act as

Indexed as

Antineoplastic AgentsCarbonic Anhydrase InhibitorsCarbonic AnhydrasesCoumarinsThioureaCell Line, TumorCell ProliferationHumansMolecular Docking SimulationStructure-Activity RelationshipAntineoplastic AgentsCarbonic Anhydrase InhibitorsCarbonic AnhydrasescoumarinCoumarinsThioureaantiproliferative activitycarbonic anhydrasescoumarinsdocking simulationsenzyme inhibitionthioureas

Identifiers

PMID42123330
PMCPMC13163854

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.