Evidence map›Paper›PMID 42123308›Full record

ArticleInternational journal of molecular sciences2026

Associations Between OPN-CD44 Axis Genetic Variability, Plasma Osteopontin, and Treatment Outcomes in Head and Neck Squamous Cell Carcinoma.

Agnieszka Gdowicz-Kłosok, Regina Deja, Tomasz Rutkowski, Magdalena Bugowska, Jolanta Mrochem-Kwarciak, Krzysztof Składowski, Dorota Butkiewicz

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Agnieszka Gdowicz-KłosokCenter for Translational Research and Molecular Biology of Cancer, Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice Branch, 44-102 Gliwice, Poland.ORCID 0000-0002-8020-258X
Regina DejaAnalytics and Clinical Biochemistry Department, Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice Branch, 44-102 Gliwice, Poland.
Tomasz RutkowskiClinical Trials Support Centre, Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice Branch, 44-102 Gliwice, Poland.ORCID 0000-0003-2735-5664
Magdalena BugowskaDepartment of Biostatistics and Bioinformatics, Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice Branch, 44-102 Gliwice, Poland.ORCID 0009-0004-3066-0285
Jolanta Mrochem-KwarciakAnalytics and Clinical Biochemistry Department, Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice Branch, 44-102 Gliwice, Poland.
Krzysztof SkładowskiI Radiation and Clinical Oncology Department, Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice Branch, 44-102 Gliwice, Poland.
Dorota ButkiewiczCenter for Translational Research and Molecular Biology of Cancer, Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice Branch, 44-102 Gliwice, Poland.ORCID 0000-0002-4043-3789

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inter-individual variability in outcomes following radiotherapy-based treatment remains a major challenge in head and neck squamous cell carcinoma (HNSCC). Osteopontin (OPN) and its receptor CD44 are key mediators of tumor progression, hypoxia-related treatment resistance, and metastatic dissemination. In this exploratory, hypothesis-generating study, we investigated selected functional polymorphisms in

Indexed as

Head and Neck NeoplasmsHyaluronan ReceptorsOsteopontinSquamous Cell Carcinoma of Head and NeckAdultAgedCarcinoma, Squamous CellFemaleHumansMaleMiddle AgedPolymorphism, Single NucleotidePrognosisTreatment OutcomeCD44 protein, humanHyaluronan ReceptorsOsteopontinSPP1 protein, humanCD44head and neck cancerOPN/SPP1osteopontinpolymorphismprognosisradiotherapytreatment response

Identifiers

PMID42123308
PMCPMC13164495

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.