Evidence map›Paper›PMID 42123138›Full record

ReviewJournal of clinical medicine2026

A Contemporary Approach to the Management of Asymptomatic Severe Aortic Stenosis.

Parth V Desai, Keerthi Gondi, Elizabeth Davis, Dantwan Smith, Alexandra V Sykes, Michael E Jessen, Lynn Huffman, Ahmed Zaghloul, Weiyi Tan, Ki Park and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Parth V DesaiCardiovascular Medicine, PLLC, Davenport, IA 52803, USA.ORCID 0000-0002-1302-0866
Keerthi GondiCardioNerds, Baltimore, MD 21209, USA.
Elizabeth DavisCardioNerds, Baltimore, MD 21209, USA.
Dantwan SmithDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.
Alexandra V SykesCardioNerds, Baltimore, MD 21209, USA.
Michael E JessenDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.ORCID 0000-0001-5031-5279
Lynn HuffmanDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.
Ahmed ZaghloulDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.ORCID 0000-0002-3647-7404
Weiyi TanDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.ORCID 0000-0003-3509-322X
Ki ParkDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.
Dharam J KumbhaniDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.ORCID 0000-0003-4321-4538
Anthony A BavryDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.ORCID 0000-0002-3731-1457
Amit GoyalCardioNerds, Baltimore, MD 21209, USA.ORCID 0000-0002-5427-7852

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Asymptomatic severe aortic stenosis (AS) is characterized by a prolonged latent phase during which progressive valvular obstruction and myocardial remodeling may occur despite preserved left ventricular ejection fraction and the absence of overt clinical symptoms. Historically, management has favored watchful waiting until symptom onset or guideline-defined triggers emerge; however, recent randomized data challenge this conservative paradigm. This review summarizes the natural history, risk stratification, and contemporary management of asymptomatic severe AS, with a focus on emerging insights that inform the timing of intervention. We propose an individualized, contemporary framework for managing asymptomatic severe AS that integrates multimodal risk assessment, procedural risk, and shared decision-making, and we outline future directions aimed at refining patient selection and optimizing the personalized timing of intervention.

Indexed as

asymptomatic severe aortic stenosiscontemporary managementearly interventionrisk stratificationsurgical aortic valve replacementtranscatheter aortic valve replacementwatchful waiting

Identifiers

PMID42123138
PMCPMC13163651

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.