ArticleSensors (Basel, Switzerland)2026
Colorimetric Detection of Arsenic (III) and Mercury (II) Ions in Human Serum Albumin Samples Using Cysteine-Capped Gold Nanoparticles.
Article in Sensors (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A continued interest in developing a low-cost, rapid screening method for quantifying Hg (II) and As (III) in biological samples stems from the toxic effects of human exposure to these heavy metal ions. This study reports the use of cysteine-capped gold nanoparticles (CysAuNPs) for chemical sensing, colorimetric detection, and quantification of As (III) and Hg (II) ions in human serum albumin (HSA) under physiological conditions. Zeta potential measurements indicated that the CysAuNPs have a negative surface charge, which was decreased in the presence of HSA and reversed to a positive value upon binding of As (III) and Hg (II) metal ions. Circular dichroism (CD) spectroscopy revealed changes in HSA conformation upon binding to As (III) and Hg (II) ions. X-ray fluorescence enables rapid qualitative screening for As (III) and Hg (II) ions before colorimetric quantification. The figures of merit (R
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