Evidence map›Paper›PMID 42122474›Full record

ArticleSensors (Basel, Switzerland)2026

Development and First-in-Human Translation of Hyperpolarized [1-

Yaewon Kim, Duy Dang, James Slater, Andrew Riselli, Donghyun Hong, Jeremy W Gordon, Susan M Chang, Yan Li, Javier E Villanueva-Meyer, Adam W Autry and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sensors (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Yaewon KimDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA.ORCID 0000-0003-1016-1572
Duy DangDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA.
James SlaterDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA.
Andrew RiselliDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA.
Donghyun HongDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA.ORCID 0000-0003-2447-2208
Jeremy W GordonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA.ORCID 0000-0003-2760-4886
Susan M ChangDepartment of Neurological Surgery, University of California, San Francisco, CA 94158, USA.
Yan LiDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA.ORCID 0000-0003-2145-2869
Javier E Villanueva-MeyerDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA.ORCID 0000-0002-5910-0757
Adam W AutryDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA.ORCID 0000-0002-7062-4965
Evelyn EscobarDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA.
Stacy AndoscaDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA.
Hsin-Yu ChenDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA.ORCID 0000-0002-2765-1685
Chou T TanISOTEC Stable Isotope Division, MilliporeSigma, Merck KGaA, Miamisburg, OH 45342, USA.
Chris SuszczynskiISOTEC Stable Isotope Division, MilliporeSigma, Merck KGaA, Miamisburg, OH 45342, USA.
Sri MaddaliISOTEC Stable Isotope Division, MilliporeSigma, Merck KGaA, Miamisburg, OH 45342, USA.
Robert A BokDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA.ORCID 0000-0003-1737-9056
Daniel B VigneronDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA.ORCID 0000-0001-5795-8699

Funding

Tissue CoreP50CA097257 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2002 to 2026
$57.4M
Project 4: Multi-modality Metabolic Imaging for Monitoring Molecular Sub-types of GliomaP01CA118816 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Pavithra Viswanath · 2007 to 2026
$44.7M
TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUAN XU · 2011 to 2026
$19.9M
Upgrade of an Obsolete 3.35T DNP Polarizer to enable new HP C-13 Technology DevelopmentS10OD025077 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VIGNERON, DANIEL B · 2020 to 2020
$1.7M
NCI NIH HHS P01 CA118816NCI NIH HHS P50 CA097257NIBIB NIH HHS P41 EB013598NIH HHS P01CA118816NIH HHS P41EB013598NIH HHS S10 OD025077University of California, San Francisco MNS7032021
6 · The paper itself

Abstract

Alpha-ketoglutarate (aKG) is a central intermediate of cerebral energy metabolism and a precursor for glutamate synthesis in the brain. Alterations in aKG metabolism occur in pathological contexts, including isocitrate dehydrogenase (IDH) mutant astrocytomas and oligodendrogliomas, in which mutant IDH converts aKG to the oncometabolite 2-hydroxyglutarate. Given its central role in brain metabolism, non-invasive interrogation of aKG-dependent metabolic flux is needed. Hyperpolarized (HP)

Indexed as

BrainKetoglutaric AcidsCarbon IsotopesGlutamic AcidHumansIsocitrate DehydrogenaseMagnetic Resonance ImagingMagnetic Resonance SpectroscopyCarbon-13Carbon IsotopesGlutamic AcidIsocitrate DehydrogenaseKetoglutaric Acidsalpha-ketoglutarateglutamatehyperpolarized 13C MRIIDH-mutants

Identifiers

PMID42122474
PMCPMC13165773

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.