ArticleSensors (Basel, Switzerland)2026
Single-Cell Selective Retrieval Method Using Cone-Shaped Light-Responsive Gas-Generating Polymer Microscaffold Array Chip.
Article in Sensors (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The detection and retrieval of specific single cells within a cell population is useful for elucidating cellular function as well as early-stage cancer diagnosis by detecting circulating tumor cells. Microcapillaries are used to retrieve specific single cells from cell populations; however, quick single-cell retrieval that firmly adheres to the substrate without damaging the cell is difficult. In this study, we propose a single-cell selective retrieval method using a cone-shaped light-responsive gas-generating polymer (LGP) microscaffold array chip. An LGP microscaffold array chip with cone-shaped LGP microscaffolds was fabricated without any special equipment. When human cervical cancer cells were spread on the LGP microscaffold array chip, adhesion was achieved, and single cells were arranged on up to 73.3% of the cone-shaped LGP microscaffolds. When low-toxicity ultraviolet A light was irradiated from the back of the LGP microscaffold array chip, only a single cell adhering to the cone-shaped LGP microscaffold was released by the generated N
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