ArticleSensors (Basel, Switzerland)2026
Nano-Power OTA-Based Low-Pass Filter for Ultra-Low-Energy Biomedical Signal Processing.
Article in Sensors (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
This paper presents a nanowatt-scale operational transconductance amplifier (OTA) and an electronically tunable third-order low-pass filter (LPF) designed for energy-constrained biomedical signal conditioning. The circuits are implemented in a 65 nm CMOS process and verified through comprehensive schematic-level simulations. Biased in the deep subthreshold region at 1 nA, the OTA achieves a 50 dB low-frequency gain, a 225 Hz unity-gain bandwidth at 10 pF load capacitance and an input-referred noise floor of 1.55 μV/√Hz, with a total power consumption of only 1.75 nW. The integrated third-order LPF provides a wide tuning range (37-668 Hz) via bias current modulation, exhibiting excellent linearity with a THD of 0.059% and a 65.3 dB dynamic range. Monte Carlo and PVT corner analyses demonstrate the design's theoretical robustness against process variations and environmental fluctuations. ECG signal simulations validate the circuit's effectiveness in suppressing high-frequency artifacts while preserving morphological integrity, providing a proof-of-concept for ultra-low-power wearable healthcare architectures.
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