Evidence map›Paper›PMID 42122276›Full record

ArticleCancers2026

Role of Maximum Standardized Uptake Volume in Predicting Tumor Spread Through Air Spaces in Stage IA Lung Cancers Smaller than 2 cm.

Massimiliano Bassi, Beatrice Zacchini, Rita Vaz Sousa, Angelina Pernazza, Paolo Graziano, Silvia De Maria, Silvia Albano, Camilla Poggi, Marco Anile, Tiziano De Giacomo and 2 more

Abstract read
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In one paragraph

Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Massimiliano BassiThoracic Surgery Unit, Department of General Surgery, Surgical Specialties and Anestesiology, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0002-2722-4974
Beatrice ZacchiniThoracic Surgery Unit, Department of General Surgery, Surgical Specialties and Anestesiology, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.
Rita Vaz SousaThoracic Surgery Unit, Department of General Surgery, Surgical Specialties and Anestesiology, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.
Angelina PernazzaDepartment of Radiological, Oncological and Pathological Sciences, Sapienza University Rome, 00161 Rome, Italy.
Paolo GrazianoDepartment of Radiological, Oncological and Pathological Sciences, Sapienza University Rome, 00161 Rome, Italy.ORCID 0000-0001-7066-7896
Silvia De MariaThoracic Surgery Unit, Department of General Surgery, Surgical Specialties and Anestesiology, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.
Silvia AlbanoThoracic Surgery Unit, Department of General Surgery, Surgical Specialties and Anestesiology, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.
Camilla PoggiThoracic Surgery Unit, Department of General Surgery, Surgical Specialties and Anestesiology, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.
Marco AnileThoracic Surgery Unit, Department of General Surgery, Surgical Specialties and Anestesiology, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0001-6785-4535
Tiziano De GiacomoThoracic Surgery Unit, Department of General Surgery, Surgical Specialties and Anestesiology, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0003-1061-5773
Federico VenutaThoracic Surgery Unit, Department of General Surgery, Surgical Specialties and Anestesiology, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.
Daniele DisoThoracic Surgery Unit, Department of General Surgery, Surgical Specialties and Anestesiology, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveRecent guidelines suggest sublobar resection as a viable option for peripheral lung cancer smaller than 2 cm. However, the presence of Spread through Air Spaces (STAS) is a well-known poor prognostic factor in early-stage lung cancer treated with sublobar resections. The aim of this study is to analyze the potential correlation between STAS and maximum standardized uptake volume (SUVmax) in this subset of patients to help define the optimal resection.

methodsA retrospective monocentric study was performed including patients diagnosed with stage IA lung cancer undergoing surgical resection. Patients were divided into two groups according to the presence/absence of STAS. As further investigation, we also separately analyzed the subgroup of patients with a peripheral nodule smaller than 2 cm. A

resultsThe study cohort consists of 121 patients, 76 (62.8%) male, with a mean age of 74.2 ± 8.8 years. STAS was observed in 67 (55.4%) cases. The STAS-positive group showed a higher SUVmax value compared to the STAS-negative one (mean 5.5 ± 4.4 vs. 3.9 ± 3.0;

conclusionsIn our study, an SUVmax ≥ 3 in preoperative 18-FDG-PET is associated with the presence of STAS in stage IA lung cancer and peripheral cancer smaller than 2 cm. These findings, integrated with other clinical and radiological data, may guide surgeons to optimize the surgical strategy.

Indexed as

lobectomylung cancermaximum standardized uptake volumePETsegmentectomySTAS

Identifiers

PMID42122276
PMCPMC13162915

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.