ArticleCancers2026
T-Cell Clonal Expansion in Peripheral Blood Following Interventional Radiology Procedures for Metastatic Liver Cancer.
Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
backgroundInterventional radiology (IR) procedures may induce anti-tumor immune responses, with subsequent clonal expansion of specific T-cells recognizing tumor antigens. This exploratory study aims to investigate the clonal expansion of T-cells in the peripheral blood after interventional radiology procedures for metastatic liver cancer.
methodsThis prospective study included 16 patients with metastatic liver cancer undergoing IR procedures (13 embolizations and 3 ablations). Biopsy samples were collected prior to the procedure, and peripheral blood samples were obtained both pre- and post-procedure. Bulk T-cell receptor (TCR) sequencing was conducted to assess T-cell clonality dynamics and to evaluate the impact of procedures on the T-cell repertoire.
resultsThe overall clonality of the T-cell repertoire in the peripheral blood did not demonstrate significant variations following IR procedures (
conclusionsIR procedures do not alter the overall clonality of the T-cell repertoire but may promote the expansion of a limited number of clonotypes. This study demonstrates that it is feasible to detect and longitudinally track expanding T-cell clonotypes following IR liver-directed therapy. Further studies are needed to determine whether these expanding clonotypes contribute to systemic anti-tumor immunity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.