Evidence map›Paper›PMID 42122163›Full record

ArticleCancers2026

Discovery of Structurally Distinct Covalent KRAS G12C Inhibitor Scaffolds Through Large-Scale In Silico Screening and Experimental Validation.

Glen J Weiss, Joseph C Loftus, David W Mallery, Nhan L Tran

Abstract read
In one paragraph

Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Glen J WeissInternational Genomics Consortium, Phoenix, AZ 85014, USA.ORCID 0000-0002-6067-597X
Joseph C LoftusDepartment of Cancer Biology, Mayo Clinic Arizona, Phoenix, AZ 85054, USA.
David W MalleryInternational Genomics Consortium, Phoenix, AZ 85014, USA.
Nhan L TranDepartment of Cancer Biology, Mayo Clinic Arizona, Phoenix, AZ 85054, USA.ORCID 0000-0003-0908-9964

Funding

International Genomics Consortium n/a
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

covalent inhibitorsKRAS G12CMM/GBSAmolecular dynamicsoncology drug discoveryresistanceswitch-II pocketvirtual screening

Identifiers

PMID42122163
PMCPMC13162765

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.