ArticleCancers2026
Patterns of Failure in Synchronous Metastatic Non-Small Cell Lung Cancer Without Driver Alterations According to Metastatic Burden.
Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
Funding
Abstract
backgroundPatterns of failure (POFs) after first-line immune checkpoint inhibitor (ICI)-based therapy in patients with synchronous metastatic non-small cell lung cancer (NSCLC) without oncogenic driver alterations may guide the selection of candidates for local consolidative therapy (LCT).
methodsWe retrospectively evaluated patients diagnosed with synchronous metastatic NSCLC between January 2017 and December 2023. Patients with oncogenic driver alterations, those who did not receive ICIs as first-line therapy, or those who lacked follow-up imaging were excluded. Patients were stratified into four groups according to the number of metastatic lesions: 1, 2, 3-5, and >5 lesions. POFs were classified as original site recurrence (OSR) or new site recurrence with or without OSR (NSR). Competing risk analyses were performed.
resultsA total of 221 patients were analyzed, with a median follow-up of 28.1 months. Initial failure patterns did not differ significantly across lesion-number groups (
conclusionsIn synchronous metastatic driver-negative NSCLC treated with first-line ICI-based therapy, both OSR and NSR were common and not clearly associated with metastatic burden, suggesting that lesion number alone may be insufficient for selecting candidates for LCT.
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