ArticleCells2026
AKT Signaling Differentially Regulates the Expression of Two Evolutionarily Conserved
Susan M Smith, Jing C Zhou, Hongqiao Zhang, Rutuja Kibe, Jason Chwa, Zhaoxia Qu, Beiyun Zhou, Parviz Minoo, Changgong Li
Abstract read
In one paragraphArticle in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
9 authors.
Susan M SmithDivision of Neonatology, Departments of Pediatrics, LAC + USC Medical Center and Children's Hospital, Los Angeles, CA 90033, USA.
Jing C ZhouDivision of Neonatology, Departments of Pediatrics, LAC + USC Medical Center and Children's Hospital, Los Angeles, CA 90033, USA.
Hongqiao ZhangHastings Center for Pulmonary Research, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.ORCID 0000-0002-0526-5636 Rutuja KibeDivision of Neonatology, Departments of Pediatrics, LAC + USC Medical Center and Children's Hospital, Los Angeles, CA 90033, USA.
Jason ChwaDivision of Neonatology, Departments of Pediatrics, LAC + USC Medical Center and Children's Hospital, Los Angeles, CA 90033, USA.
Zhaoxia QuHastings Center for Pulmonary Research, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.ORCID 0000-0002-2769-9814 Beiyun ZhouHastings Center for Pulmonary Research, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Parviz MinooDivision of Neonatology, Departments of Pediatrics, LAC + USC Medical Center and Children's Hospital, Los Angeles, CA 90033, USA.
Changgong LiDivision of Neonatology, Departments of Pediatrics, LAC + USC Medical Center and Children's Hospital, Los Angeles, CA 90033, USA.ORCID 0000-0002-8534-8190 Funding
Structural and molecular dissection of NF-kappaB regulation by the ubiquitin E3 ligase PDLIM2 in lung innate immunity and diseasesR01GM144890 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI QU, ZHAOXIA, XIAO, GUTIAN · 2022 to 2025
$2.1MMechanistic difference of NF-kappaB in lung physiology and tumorigenesisR01CA258614 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Zhaoxia Qu, GUTIAN XIAO · 2022 to 2026
$1.9MThe NF-kappaB modulator PDLIM2 as an intrinsic checkpoint of alveolar macrophages critical for lung innate immunity, inflammation and diseasesR01HL177140 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Zhaoxia Qu · 2025 to 2026
$1.6MHastings Foundation GF1017812National Institute of Health HL144932NCI NIH HHS R01 CA258614NHLBI NIH HHS R01 HL177140NIGMS NIH HHS R01 GM144890NIH HHS GM144890NIH HHS HL114959NIH HHS HL176777NIH HHS HL177140State of California T34IR7962
6 · The paper itselfAbstract
WNT5a is a lipid-modified glycoprotein member of the WNT family of signaling molecules. Two isoforms of WNT5a have been identified that are conserved across mice and humans. These isoforms display specific functions in regulating cancer cell activities. While WNT5a is, indeed, essential for normal lung development and homeostasis, and is dysregulated in multiple lung diseases, little to no information is available regarding the expression or potential function of WNT5a isoforms in normal or diseased lungs. Such information has the potential to help to elucidate the more precise and nuanced functions of WNT5a in various pulmonary conditions. In this study, we characterized the expression of individual
Indexed as
LungProto-Oncogene Proteins c-aktWnt-5a ProteinAcute Lung InjuryAnimalsBleomycinFibroblastsHumansMiceMice, Inbred C57BLProtein IsoformsPulmonary FibrosisSignal TransductionBleomycinProtein IsoformsProto-Oncogene Proteins c-aktWnt-5a ProteinWnt5a protein, mouseAKTERKfibrosislung injuryWNT5a isoformsWNT signaling
Identifiers
PMID42121944
PMCPMC13162999
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390