ArticleCells2026
A Longitudinal Murine Model Reveals Biphasic T Cell Remodeling and Progressive Skeletal Deterioration Under Chronic High-Salt Exposure.
Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Excessive dietary sodium intake has been associated with immune dysregulation, yet its impact on bone health and immune cell dynamics within the bone-immune axis remains poorly understood. We developed a longitudinal murine model to investigate the effects of a high-salt diet (HSD) on bone properties and immunity. Male and female C57BL/6J and Foxp3-GFP mice underwent unilateral nephrectomy and were fed either a normal salt diet (0.2% NaCl) or HSD (4% NaCl) for 20, 60, or 150 days. HSD mice exhibited a transient increase in systolic blood pressure and sustained calciuria without changes in serum calcium or PTH. Progressive impairment of femoral strength and tibial trabecular microarchitecture were observed, along with reduced cortical calcium and phosphorus content. Immune analysis revealed early splenic and bone marrow activation of effector T cells, with increased Th17 and Tc17 populations and a disrupted Th17/Treg balance at 20 days. These changes normalized by 60 days and shifted to suppressed T cell activation at 150 days, suggesting a biphasic immune response. Th17/Treg ratio was associated with bone deterioration. Notably, both sexes showed comparable physiological and immune trends. This integrative model provides a platform to dissect mechanisms linking chronic salt overload, immune dysregulation, and bone fragility.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.