Evidence map›Paper›PMID 42121922›Full record

ArticleCells2026

Latrophilin-1-Mediated G

Evelina Petitto, Frédéric A Meunier, Sara Fidalgo, Cesare Colasante, Jennifer K Blackburn, Richard R Ribchester, Yuri A Ushkaryov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Evelina PetittoMedway School of Pharmacy, University of Kent and Greenwich, Central Avenue, Chatham Maritime ME4 4TB, UK.ORCID 0000-0001-9814-9660
Frédéric A MeunierDivision of Cell and Molecular Biology, Imperial College London, Exhibition Road, London SW7 2AZ, UK.ORCID 0000-0001-6400-1107
Sara FidalgoDivision of Cell and Molecular Biology, Imperial College London, Exhibition Road, London SW7 2AZ, UK.ORCID 0000-0001-8987-6196
Cesare ColasanteUnité d'Embryologie Moléculaire, Institut Pasteur, Unités de Recherche Associées 2578, Centre National de la Recherche Scientifique, 25 Rue du Dr Roux, 75724 Paris, France.
Jennifer K BlackburnMedway School of Pharmacy, University of Kent and Greenwich, Central Avenue, Chatham Maritime ME4 4TB, UK.ORCID 0000-0002-2171-6716
Richard R RibchesterBiomedical Sciences, University of Edinburgh, George Square, Edinburgh EH8 9JZ, UK.ORCID 0000-0003-2670-6995
Yuri A UshkaryovMedway School of Pharmacy, University of Kent and Greenwich, Central Avenue, Chatham Maritime ME4 4TB, UK.ORCID 0000-0002-5712-8297

Funding

Biotechnology and Biological Sciences Research Council 28/B14085Biotechnology and Biological Sciences Research Council BB/D523078/1Wellcome Trust GR074359
6 · The paper itself

Abstract

Latrophilin 1 (LPHN1/ADGRL1), an adhesion G-protein-coupled receptor (GPCR), is the principal receptor for α-latrotoxin (αLTX), a toxin that triggers massive neurotransmitter release. However, its endogenous signaling mechanism remains elusive. Here, we dissect the LPHN1 signaling pathway at the vertebrate neuromuscular junction, using the pore-deficient αLTX mutant LTX

Indexed as

CalciumCalcium Channels, N-TypeExocytosisGTP-Binding Protein alpha Subunits, Gq-G11Neuromuscular JunctionReceptors, G-Protein-CoupledReceptors, PeptideAnimalsCalcium SignalingMiceMice, KnockoutSignal TransductionSpider Venomsalpha-latrotoxinalpha-latrotoxin receptorCacna1b protein, mouseCalciumCalcium Channels, N-TypeGTP-Binding Protein alpha Subunits, Gq-G11Receptors, G-Protein-CoupledReceptors, PeptideSpider VenomsADGRL1Ca2+ storesCaV2.1exocytosisG-protein-coupled receptorslatrophilin-1neuromuscular junctionneurotransmitter releasepresynapticsignalingstore-operated Ca2+ entry

Identifiers

PMID42121922
PMCPMC13162755

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.