Intersection of Sphingolipid and Sterol Metabolism at the Level of Orm Proteins in Yeast.

Francesca Barone, Stéphanie Cottier, Jiri Stribny, Michele Visentin, Roger Schneiter, Museer A Lone

Abstract read

In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Francesca BaroneDepartment of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, 8952 Zurich, Switzerland.

Stéphanie CottierDepartment of Biology, University of Fribourg, Chemin du Musée 10, 1700 Fribourg, Switzerland.

Jiri StribnyDepartment of Biology, University of Fribourg, Chemin du Musée 10, 1700 Fribourg, Switzerland.

Michele VisentinDepartment of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, 8952 Zurich, Switzerland.

Roger SchneiterDepartment of Biology, University of Fribourg, Chemin du Musée 10, 1700 Fribourg, Switzerland.ORCID 0000-0002-9102-8396

Museer A LoneInstitute of Clinical Chemistry, University Hospital Zurich, University of Zurich, 8952 Zurich, Switzerland.ORCID 0000-0001-9710-775X

Funding

EMPIRIS foundation NANext Generation EU DM 1557 11.10.2022Next Generation EU Investment PE8 - Project Age-ItSchweiz Stiftung für die Erforschung der Muskelkrankheiten (FSRMM) NASwiss National Science Foundation 310030_207870

6 · The paper itself

Abstract

Sterols and sphingolipids assemble into specialized membrane microdomains that are essential for membrane function, protein sorting, and signal transduction. Although coordinated regulation between sterol and sphingolipid metabolic pathways has long been recognized, the molecular mechanisms mediating this cross-talk remain incompletely defined. Here, we uncover an unanticipated role for the conserved yeast Orm proteins in controlling sterol and neutral lipid homeostasis. Deletion of

Indexed as

Saccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSphingolipidsSterolsLipid MetabolismOrm1 protein, S cerevisiaeOrm2 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsSphingolipidsSterolsinositol auxotrophymembrane microdomainsneutral lipid mobilizationserine-palmitoyltransferase (SPT)sphingolipidssterolssteryl estersterbinafine

Identifiers

PMID42121915

DOI10.3390/cells15090814

PMCPMC13162685

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.