Evidence map›Paper›PMID 42121894›Full record

ArticleCells2026

Suppression of Tau Phosphorylation Induces Neurotoxicity, Causing Developmental Defects and Degeneration in

Man Pok Lu, Yi Rong, Jingyi Wang, Xiaochun Yu, Hongjiang Liu, Yingjie Wu, Minxing Zhang, Yining Chen, Yidong Li, Yuner Yan and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Man Pok LuQueensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.ORCID 0000-0003-0126-0931
Yi RongQueensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.ORCID 0000-0003-2028-8497
Jingyi WangQueensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.ORCID 0009-0004-0016-7246
Xiaochun YuQueensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.
Hongjiang LiuQueensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.
Yingjie WuQueensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.
Minxing ZhangQueensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.
Yining ChenQueensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.ORCID 0009-0004-9865-4754
Yidong LiQueensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.
Yuner YanQueensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.
Aiden LiuCollege of Engineering, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-0309-7018
Zhaoyu LiQueensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.ORCID 0000-0002-5222-6832

Funding

Bartlett Senior Research Fellowship To Z. L.NHMRC Ideas grant GNT2002472Queensland Brain Institute start-up funding To Z. L.
6 · The paper itself

Abstract

Tau hyperphosphorylation is a hallmark of tauopathies and is closely associated with neurodegeneration. While targeting kinases and phosphatases to suppress tau phosphorylation has become an increasingly attractive therapeutic approach, the functional significance of tau phosphorylation and the potential risks of suppressing this process are not fully understood. Using

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsNerve Degenerationtau ProteinsAnimalsMicrotubulesMutationNeuritesPhosphorylationCaenorhabditis elegans Proteinstau ProteinsC. elegansC-terminal region (CTR)hTauAPhTauE14microtubule-binding domain (MTB)tau phosphorylation

Identifiers

PMID42121894
PMCPMC13163045

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.