Evidence map›Paper›PMID 42121892›Full record

SynthesisCells2026

Alpelisib in PIK3CA-Related Overgrowth Spectrum (PROS): A Systematic Review of Real-World Evidence in over 100 Patients.

Francesco Pellegrino, Giuseppe Reynolds, Simona Cardaropoli, Maria Luca, Stefania Massuras, Diana Carli, Alessandro Mussa

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Francesco PellegrinoDepartment of Public Healthcare and Pediatrics, University of Torino, 10124 Torino, Italy.ORCID 0000-0002-4353-8324
Giuseppe ReynoldsDepartment of Public Healthcare and Pediatrics, University of Torino, 10124 Torino, Italy.ORCID 0000-0003-0447-2112
Simona CardaropoliDepartment of Public Healthcare and Pediatrics, University of Torino, 10124 Torino, Italy.ORCID 0000-0002-8927-8900
Maria LucaPediatric Clinical Genetics Unit, Regina Margherita Children Hospital, 10126 Torino, Italy.ORCID 0009-0006-1239-0829
Stefania MassurasDepartment of Public Healthcare and Pediatrics, University of Torino, 10124 Torino, Italy.ORCID 0009-0002-4679-2982
Diana CarliPediatric Clinical Genetics Unit, Regina Margherita Children Hospital, 10126 Torino, Italy.ORCID 0000-0001-5690-6504
Alessandro MussaDepartment of Public Healthcare and Pediatrics, University of Torino, 10124 Torino, Italy.

Funding

Italian Society of Pediatrics SIP 2023 Pediatric Research Call
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Class I Phosphatidylinositol 3-KinasesChildChild, PreschoolHumansThiazolesAlpelisibClass I Phosphatidylinositol 3-KinasesPIK3CA protein, humanThiazolesalpelisibPI3K pathwayPIK3CA-related overgrowth spectrumPROStargeted therapy

Identifiers

PMID42121892
PMCPMC13162736

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.