Evidence map›Paper›PMID 42121861›Full record

ArticleCells2026

Involvement of TRPA1 in Necrosis of Melanoma Cells via Phospholipase D1.

Rei Nakano, Manami Kuji, Mana Sugimura, Naoya Yachiku, Nanako Kitanaka, Taku Kitanaka, Yoko Suwabe, Atsuto Naruke, Junichi Nunomura, Masami Uechi and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rei NakanoLaboratory for Mucosal Immunity, RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Kanagawa, Japan.ORCID 0000-0003-0255-6347
Manami KujiLaboratory of Veterinary Radiotherapy, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa 252-0880, Kanagawa, Japan.
Mana SugimuraLaboratory of Veterinary Radiotherapy, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa 252-0880, Kanagawa, Japan.
Naoya YachikuLaboratory of Veterinary Radiotherapy, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa 252-0880, Kanagawa, Japan.
Nanako KitanakaLaboratory of Veterinary Radiotherapy, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa 252-0880, Kanagawa, Japan.
Taku KitanakaLaboratory of Veterinary Radiotherapy, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa 252-0880, Kanagawa, Japan.ORCID 0009-0003-9766-3715
Yoko SuwabeLaboratory of Veterinary Radiotherapy, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa 252-0880, Kanagawa, Japan.
Atsuto NarukeLaboratory of Veterinary Radiotherapy, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa 252-0880, Kanagawa, Japan.
Junichi NunomuraLaboratory of Veterinary Radiotherapy, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa 252-0880, Kanagawa, Japan.
Masami UechiJapan Animal Specialty Medical Institute, Tsuzuki-ku, Yokohama 224-0001, Kanagawa, Japan.ORCID 0000-0001-9924-0335
Tomohiro NakayamaLaboratory of Veterinary Radiotherapy, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa 252-0880, Kanagawa, Japan.ORCID 0000-0002-0435-5314
Hiroshi SugiyaJapan Animal Specialty Medical Institute, Tsuzuki-ku, Yokohama 224-0001, Kanagawa, Japan.

Funding

Ministry of Education, Culture, Sports, Science and Technology of Japan 18K14594Ministry of Education, Culture, Sports, Science and Technology of Japan 19K06389
6 · The paper itself

Abstract

The tumor microenvironment, including extracellular pH (pH

Indexed as

MelanomaPhospholipase DTRPA1 Cation ChannelApoptosisCalciumCell Line, TumorCell SurvivalHumansHydrogen-Ion ConcentrationIsothiocyanatesNecrosisallyl isothiocyanateCalciumIsothiocyanatesPhospholipase Dphospholipase D1TRPA1 Cation ChannelTRPA1 protein, humanCa2+ influxcell deathmelanomaphosphatidylcholine-specific phospholipase D1transient receptor potential ankyrin 1

Identifiers

PMID42121861
PMCPMC13162945

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.