Transcriptomic Response and Molecular Adaptation Mechanisms of Common Carp (

Xiaoying Jiang, Junli Zheng, Zilong Jiang, Yiyu Cao, Ying Jiang, Wei Hu, Deliang Li, Fan Yu

Abstract read

In one paragraph

Article in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaoying JiangCollege of Fisheries, Hunan Agricultural University, Changsha 410128, China.

Junli ZhengState Key Laboratory of Developmental Biology of Freshwater Fish, Engineering Research Center of Polyploid Fish Reproduction and Breeding of the State Education Ministry, College of Life Sciences, Hunan Normal University, Changsha 410081, China.

Zilong JiangCollege of Fisheries, Hunan Agricultural University, Changsha 410128, China.

Yiyu CaoCollege of Fisheries, Hunan Agricultural University, Changsha 410128, China.

Ying JiangCollege of Fisheries, Hunan Agricultural University, Changsha 410128, China.

Wei HuState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.

Deliang LiCollege of Fisheries, Hunan Agricultural University, Changsha 410128, China.

Fan YuCollege of Fisheries, Hunan Agricultural University, Changsha 410128, China.

Funding

he State Key Laboratory of Breeding Biotechnology and Sustainable Aquacultur 2025BBSA10the National Natural Science Foundation 31872583

6 · The paper itself

Abstract

This study employed a 2 × 2 factorial design to investigate the transcriptomic responses of common carp intestine under the single and combined stress of high temperature and zinc. Results from Illumina RNA-seq, WGCNA, and qPCR showed high-quality sequencing data with good reproducibility. High temperature was the core driver of global transcriptomic reprogramming, inducing numerous DEGs via activating metabolic and stress signaling pathways. Zinc alleviated heat stress by reducing DEGs by 43.2% and activating DNA repair and cell cycle pathways. WGCNA identified core modules for heat response and zinc mitigation, revealing "emergency defense" and "repair adaptation" strategies. This study enriches the teleost stress adaptation theory and provides a scientific basis for healthy carp aquaculture.

Indexed as

Cyprinus carpioheat stressintestinal tissuetranscriptomezinc

Identifiers

PMID42121754

DOI10.3390/ani16091334

PMCPMC13162933

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.