ArticleHealthcare (Basel, Switzerland)2026
Temporal Changes in Affective Symptoms, Headache Burden, and Quality of Life Following rTMS Treatment in Migraine: A Longitudinal Study.
Article in Healthcare (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundMigraine is frequently associated with anxiety, depression, and reduced quality of life, contributing to substantial functional impairment.
objectiveTo examine longitudinal changes in affective symptoms, headache-related burden, and quality of life following repetitive transcranial magnetic stimulation (rTMS) in individuals with migraine.
methodsIn this one-arm longitudinal study, 32 adults with migraine underwent 10 sessions of rTMS. Anxiety (HAMA), depression (HAMD), and migraine-specific quality of life were assessed at baseline, post-treatment, and 3-month follow-up, while headache impact (HIT-6) and disability (MIDAS) were evaluated at baseline and post-treatment. Repeated-measures analyses and paired comparisons were conducted.
resultsSignificant improvements over time were observed for anxiety, depression, and quality of life (all
conclusionsrTMS was associated with improvements in affective symptoms, migraine-related burden, and quality of life. However, given the one-arm design, these findings should be interpreted cautiously. Controlled studies are needed to confirm these results.
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