Evidence map›Paper›PMID 42121549›Full record

ArticleFoods (Basel, Switzerland)2026

10-Hydroxy-2-decenoic Acid Suppresses Colorectal Cancer Progression by Inhibiting Wnt/β-Catenin Signaling and Promoting Apoptosis.

Yan Lin, Rongjing Cai, Lei Huang, Tianxing Lin, Anqi Lin, Zhenyu Lin, Shoujie Jiang, Yuqi Zhu, Yuan Yuan, Songkun Su

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Foods (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yan LinCollege of Bee Science and Biomedicine, Fujian Agriculture and Forestry University, Fuzhou 350002, China.ORCID 0000-0002-0351-3763
Rongjing CaiCollege of Bee Science and Biomedicine, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Lei HuangCollege of Bee Science and Biomedicine, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Tianxing LinCollege of Bee Science and Biomedicine, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Anqi LinCollege of Bee Science and Biomedicine, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Zhenyu LinCollege of Bee Science and Biomedicine, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Shoujie JiangCollege of Bee Science and Biomedicine, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Yuqi ZhuCollege of Bee Science and Biomedicine, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Yuan YuanCollege of Bee Science and Biomedicine, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Songkun SuCollege of Bee Science and Biomedicine, Fujian Agriculture and Forestry University, Fuzhou 350002, China.

Funding

Central Guidance on Local Science and Technology Development Fund of Fujian Province 2024L3006China Agriculture Research System of MOF, and MARA CARS-44Innovation and Entrepreneurship Training Program of Fujian Agriculture and Forestry University FAFUXMPC20250429001-00411National Natural Science Foundation of China 32272938Natural Science Foundation of Fujian Province 2023J01490
6 · The paper itself

Abstract

Colorectal cancer (CRC) remains a leading cause of cancer-related death worldwide, and advanced disease continues to show poor prognosis due to therapeutic limitations and drug resistance. Royal jelly (RJ), a natural functional food and dietary supplement, contains 10-hydroxy-2-decenoic acid (10-HDA), a bioactive fatty acid unique to RJ with demonstrated anticancer potential. This study evaluated the anti-CRC effects and underlying mechanisms of 10-HDA through cellular, animal, and transcriptomic approaches. 10-HDA markedly suppressed CRC cell viability with IC

Indexed as

10-hydroxy-2-decenoic acidapoptosiscolorectal cancerroyal jellyWnt/β-catenin pathway

Identifiers

PMID42121549
PMCPMC13163642

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.