Prebiotic-Empowered Probiotics with Gastrointestinal Stress Resistance for Enhanced Oral Therapy of Immunosuppression.

Xiaomin Chen, Huangxin Zhu, Zuwei Liu, Qianru Zhao, Ying Zhang, Yiqun Wan, Hao Wan

Abstract read

In one paragraph

Article in Foods (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaomin ChenState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, China.

Huangxin ZhuJiangxi Provincial Key Laboratory of Digestive Diseases, Department of Gastroenterology, Jiangxi Clinical Research Center for Gastroenterology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330066, China.

Zuwei LiuState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, China.

Qianru ZhaoState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, China.

Ying ZhangState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, China.

Yiqun WanState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, China.ORCID 0000-0001-9596-6163

Hao WanState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, China.ORCID 0000-0002-9990-2359

Funding

National Natural Science Foundation of China 32372322National Natural Science Foundation of China 82503553Natural Science Foundation of Jiangxi Province 20224ACB215009Natural Science Foundation of Jiangxi Province 20232ACB205024Natural Science Foundation of Jiangxi Province 20242BAB21029The Central Guidance Fund for Local Science and Technology Development in Jiangxi Province 20252ZDD020002The China Postdoctoral Science Foundation 2025M783001The China Postdoctoral Science Foundation GZC20251940Young Scientists Fund of the Natural Science Foundation of Jiangxi Province 20252BAC200650Young Talent Cultivation Program of Nanchang University XX202506030014

6 · The paper itself

Abstract

Oral probiotic-based therapy has emerged as a promising solution with multifaceted benefits for immunosuppression treatment. However, their widespread and clinical utility is severely limited by the poor viability of probiotics under harsh gastrointestinal conditions in the intestine. To address these challenges, a probiotic-based biohybrid (Lr@DGN) was bio-orthogonally fabricated by covalently anchoring the prebiotic β-glucan (GN) to the probiotic

Indexed as

biorthogonal engineeringimmunosuppressionLimosilactobacillus reuteriβ-glucan

Identifiers

PMID42121483

DOI10.3390/foods15091540

PMCPMC13164192

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.