Evidence map›Paper›PMID 42121334›Full record

ArticlePhysiological reports2026

Clinical measurements of aortic stiffness and peripheral resistance using a routine echocardiogram.

Maggie Gudenkauf, Senthil Kumar, Noah D Manring

Abstract read
In one paragraph

Article in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Maggie GudenkaufMechanical and Aerospace Engineering, University of Missouri, Columbia, Missouri, USA.
Senthil KumarUniversity of Missouri Hospital, Columbia, Missouri, USA.
Noah D ManringUniversity of Missouri Hospital, Columbia, Missouri, USA.ORCID 0000-0002-5650-9506

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Retrospective data for 259 patients is used to calculate aortic stiffness based on a new method which has been previously verified with in-vitro and in-hospital carotid-femoral Pulse Wave Velocity (cfPWV) studies. For this group of patients, it is shown that the greatest variability within the hemodynamic record is the aortic stiffness, followed by the peripheral resistance - both present risk factors for cardiovascular disease. Our research shows that elevated stiffness is observed in both hypotensive and hypertensive patients, while the peripheral resistance increases monotonically with hypertensive grade. Our research also shows that stiffness and resistance decrease with increasing BMI which may indicate secondary causes for the obesity paradox documented in previous studies.

Indexed as

EchocardiographyHypertensionVascular ResistanceVascular StiffnessFemaleHumansMaleMiddle AgedObesityPulse Wave Analysisaortic stiffnessechocardiogramobesity paradox

Identifiers

PMID42121334
PMCPMC13167701

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.