Evidence map›Paper›PMID 42121280›Full record

ReviewActa physiologica (Oxford, England)2026

Ca

Christian Aalkjær, Vibeke Secher Dam, Holger Nilsson, Donna B Boedtkjer, Vladimir Matchkov

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Acta physiologica (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Christian AalkjærDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0003-2618-4015
Vibeke Secher DamDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Holger NilssonDepartment of Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID https://orcid.org/0000-0003-2350-7157
Donna B BoedtkjerDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Vladimir MatchkovDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0002-3303-1095

Funding

Danmarks Frie Forskningsfond 3101-00103BLundbeck Foundation R344-2020-952Lundbeck Foundation R412-2022-449
6 · The paper itself

Abstract

aimCa

methodsIn this review, we discuss the possibility that members of the two families, bestrophins and TMEM16A, may interact.

resultsIn the cardiovascular system, the evidence is strongest. Here (1) TMEM16A and bestrophin-3 are closely located in the membrane, (2) TMEM16A may regulate the expression of bestrophin-3, and (3) a cGMP dependent Ca

conclusionWe conclude that there is evidence for direct interaction between TMEM16A and bestrophins in the cardiovascular system, and it will be important to determine whether similar interactions extend to other tissues.

Indexed as

CalciumChloride ChannelsNeoplasm ProteinsAnimalsAnoctamin-1BestrophinsHumansANO1 protein, humanAnoctamin-1BestrophinsCalciumChloride ChannelsNeoplasm Proteins

Identifiers

PMID42121280
PMCPMC13168367

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.