Evidence map›Paper›PMID 42121270›Full record

ReviewStem cell research & therapy2026

Emerging therapeutic potential of umbilical cord-derived extracellular vesicles in lung-injurious diseases: a review of recent advances.

Shuzhe Xiao, Lingling Wang, Xu Li, Qi Zheng, Lewen Zhou, Xiaoyan Song, Jie Yang

Abstract readReview
In one paragraph

Review in Stem cell research & therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shuzhe Xiao *Department of Neonatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Lingling Wang *The First Clinical Medical College of Southern Medical University, Guangzhou, 510515, China.
Xu LiDepartment of Neonatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Qi ZhengThe First Clinical Medical College of Southern Medical University, Guangzhou, 510515, China.
Lewen ZhouThe First Clinical Medical College of Southern Medical University, Guangzhou, 510515, China.
Xiaoyan SongDepartment of Neonatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Jie YangDepartment of Neonatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. Jieyang0830@126.com.

Funding

National Natural Science Foundation of China 82171714
6 · The paper itself

Abstract

Recent research has shown that extracellular vesicles (EVs) have significant potential in treating lung injuries. These vesicles facilitate communication between cells and regulate important biological processes, including cell growth, blood vessel formation, and inflammatory responses. Due to their natural ability to cross biological barriers and low risk of immune rejection, EVs are potential vehicles for targeted drug delivery. Among various biological sources, umbilical cord-derived EVs are highly advantageous because the collection process is non-invasive and provides a high yield of vesicles. Preclinical studies have demonstrated their therapeutic potential in conditions such as bronchopulmonary dysplasia, chronic obstructive pulmonary disease, acute respiratory distress syndrome, and asthma. This review summarizes the current evidence supporting the use of umbilical cord-derived EVs for lung diseases. It also discusses key translational challenges, such as manufacturing scalability and product consistency, alongside advanced engineering strategies for future clinical use.

Indexed as

AsthmaBronchopulmonary DysplasiaExtracellular VesiclesLung InjuryPulmonary Disease, Chronic ObstructiveUmbilical CordAnimalsHumansEngineeringExtracellular vesiclesLung injuryTherapeutic potentialUmbilical cord

Identifiers

PMID42121270
PMCPMC13421093

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.