ArticleJournal of biological engineering2026
From polyclonal to monoclonal: de novo sequencing of goat antibodies for a standardized ApoA-I immunoturbidimetric assay.
Article in Journal of biological engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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14 authors.
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Abstract
Antibodies serve as essential recognition elements in in vitro diagnostics (IVD), yet reliance on polyclonal antibodies (pAbs) introduces significant challenges related to batch-to-batch consistency. To address this, we employed a de novo sequencing platform, which identified 15 candidate monoclonal antibody (mAb) sequences. From these, four distinct mAb mixtures were formulated and evaluated. Using an immunoturbidimetric assay to quantify apolipoprotein A-I (ApoA-I) in 105 human serum samples, the performance of these mixtures was compared to that of a conventional pAb reagent. The four-mAb mixture demonstrated excellent correlation with the pAb assay (Passing-Bablok: y = 1.0536x-0.0748 g/L; r
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