Evidence map›Paper›PMID 42121216›Full record

ReviewJournal of translational medicine2026

Cognitive frailty research (2001-2024): a scientometric analysis of its evolution, intellectual structure, and future frontiers.

Ruirui Zhang, Shenglin Wang, Yaqing Liu, Yuanhang Xu, Sirui Chen, Xuejuan Liu, Junqiang Li, Lingxin Ren, Xin Tian, Tiancheng Wang

Abstract readReview
In one paragraph

Review in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ruirui Zhang *Department of Neurology, Epilepsy Center, The Second Hospital & Clinical Medical School, Lanzhou University, 82 Cuiyingmen Street, Chengguan District, Lanzhou, Gansu, 730030, China.
Shenglin Wang *Department of Geriatrics, Laboratory of Research and Translation for Geriatric Diseases, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong District, Chongqing, 400016, China.
Yaqing LiuDepartment of Neurology, Epilepsy Center, The Second Hospital & Clinical Medical School, Lanzhou University, 82 Cuiyingmen Street, Chengguan District, Lanzhou, Gansu, 730030, China.
Yuanhang XuDepartment of Neurology, Epilepsy Center, The Second Hospital & Clinical Medical School, Lanzhou University, 82 Cuiyingmen Street, Chengguan District, Lanzhou, Gansu, 730030, China.
Sirui ChenDepartment of Neurology, Epilepsy Center, The Second Hospital & Clinical Medical School, Lanzhou University, 82 Cuiyingmen Street, Chengguan District, Lanzhou, Gansu, 730030, China.
Xuejuan LiuDepartment of Neurology, Epilepsy Center, The Second Hospital & Clinical Medical School, Lanzhou University, 82 Cuiyingmen Street, Chengguan District, Lanzhou, Gansu, 730030, China.
Junqiang LiDepartment of Neurology, Epilepsy Center, The Second Hospital & Clinical Medical School, Lanzhou University, 82 Cuiyingmen Street, Chengguan District, Lanzhou, Gansu, 730030, China.
Lingxin RenDepartment of Geriatrics, Laboratory of Research and Translation for Geriatric Diseases, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong District, Chongqing, 400016, China.
Xin TianDepartment of Geriatrics, Laboratory of Research and Translation for Geriatric Diseases, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong District, Chongqing, 400016, China. xintian@cqmu.edu.cn.
Tiancheng WangDepartment of Neurology, Epilepsy Center, The Second Hospital & Clinical Medical School, Lanzhou University, 82 Cuiyingmen Street, Chengguan District, Lanzhou, Gansu, 730030, China. wangtch@lzu.edu.cn.ORCID 0000-0001-9701-8845

Funding

Gansu Provincial Joint Research Fund 23JRRA1504Lanzhou Science and Technology Plan Project 2024-3-85Major Project of Science and Technology Innovation in Gansu Provincial Health Industry GSWSZD2025-12National Natural Science Foundation of China 82160262
6 · The paper itself

Abstract

backgroundCognitive frailty (CF), the co-existence of physical frailty and non-dementia cognitive impairment, has emerged as a critical geriatric syndrome and prevention target since the 2013 international consensus. However, a systematic quantification of its complete evolutionary trajectory and knowledge structure remains lacking.

methodsWe conducted a comprehensive scientometric analysis of 422 publications (2001-2024) retrieved from the Web of Science Core Collection. We employed document co-citation analysis, keyword co-occurrence, and burst detection to map the field's trajectory, thematic structure, and research frontiers.

resultsThe field evolved through three distinct stages: a pre-2013 germination phase, a 2013-2021 formation phase, and a post-2021 deepening phase. Co-citation analysis identified 13 major thematic clusters, with the 2013 consensus paper being the most cited work (LCS = 301, GCS = 755). Keyword burst analysis revealed 37 high-intensity burst terms, with recent bursts (post-2021) concentrated in psychosocial domains, such as social frailty, depression, and sleep quality, indicating a paradigm shift from a biomedical to a biopsychosocial model.

conclusionsThis study provides the first full life-cycle knowledge map of CF research, demonstrating its transition from descriptive epidemiology to preventive intervention. This scientometric roadmap serves as a practical tool for researchers to identify knowledge gaps and collaboration opportunities, and for clinicians to understand the evidence base for multidomain assessment and intervention. It provides a data-driven foundation for accelerating translational research and implementing effective preventive or reversal strategies.

Indexed as

BibliometricsBiomedical ResearchCognitionFrailtyHumansBiopsychosocial modelCognitive frailtyPreventionResearch frontiersScience mapping

Identifiers

PMID42121216
PMCPMC13169790

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.